SCM
SEPN

Soleus Capital Management’s Septerna Inc SEPN Stock Holding History

Soleus Capital Management’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$6.61M Sell
275,000
-108,368
-28% -$2.85M 0.27% 58
2025
Q4 		$10.7M Buy
383,368
+365,108
+1,999% +$8.72M 0.39% 50
2025
Q3 		$343K Sell
18,260
-57,196
-76% -$751K 0.02% 85
2025
Q2 		$798K Sell
75,456
-675,897
-90% -$5.57M 0.05% 88
2025
Q1 		$4.35M Buy
751,353
+75,944
+11% +$867K 0.31% 52
2024
Q4 		$15.5M Buy
+675,409
New +$16M 0.97% 33

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Soleus Capital Management's SEPN Position: Q1 2026 in Review

Soleus Capital Management reduced its Septerna Inc (SEPN) stake by 28% in Q1 2026, selling an estimated $2.85M and leaving 275,000 shares worth $6.61M. The position accounts for 0.27% of the portfolio, ranked #58.

Soleus Capital Management first reported a position in SEPN in Q4 2024 and has held it in 6 quarters since. The position peaked at $15.5M in Q4 2024. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • Soleus Capital Management held 275,000 shares of Septerna Inc worth $6.61M as of Q1 2026.
  • Soleus Capital Management sold 108,368 Septerna Inc shares in Q1 2026, an estimated $2.85M.
  • Septerna Inc made up 0.27% of Soleus Capital Management's portfolio in Q1 2026, its #58 holding.
  • Soleus Capital Management first reported a position in Septerna Inc in Q4 2024 and has held it in 6 quarters since.
  • Soleus Capital Management's Septerna Inc position peaked at $15.5M in Q4 2024.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Soleus Capital Management's 13F filing for Q1 2026, filed 14 May 2026.