DCM
SEPN

Driehaus Capital Management’s Septerna Inc SEPN Stock Holding History

Driehaus Capital Management’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$148M Buy
4,433,058
+37,486
+0.9% +$1.06M 0.86% 18
2026
Q1 		$106M Sell
4,395,572
-413,898
-9% -$10.9M 0.78% 25
2025
Q4 		$134M Sell
4,809,470
-110,426
-2% -$2.64M 0.91% 16
2025
Q3 		$92.5M Buy
4,919,896
+239,465
+5% +$3.14M 0.66% 34
2025
Q2 		$49.5M Buy
4,680,431
+1,557,823
+50% +$12.8M 0.4% 82
2025
Q1 		$18.1M Buy
3,122,608
+533,055
+21% +$6.09M 0.17% 172
2024
Q4 		$59.3M Buy
+2,589,553
New +$61.2M 0.49% 65

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $232M AUM 247.08% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.22B AUM 242.83% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

Driehaus Capital Management's SEPN Position: Q2 2026 in Review

Driehaus Capital Management increased its Septerna Inc (SEPN) stake by 0.85% in Q2 2026, buying an estimated $1.06M and bringing the position to 4,433,058 shares worth $148M. The position accounts for 0.86% of the portfolio, ranked #18.

Driehaus Capital Management first reported a position in SEPN in Q4 2024 and has held it in 7 quarters since. 153 funds tracked by Wall St. Rank hold SEPN as of Q2 2026.

  • Driehaus Capital Management held 4,433,058 shares of Septerna Inc worth $148M as of Q2 2026.
  • Driehaus Capital Management bought 37,486 Septerna Inc shares in Q2 2026, an estimated $1.06M.
  • Septerna Inc made up 0.86% of Driehaus Capital Management's portfolio in Q2 2026, its #18 holding.
  • Driehaus Capital Management first reported a position in Septerna Inc in Q4 2024 and has held it in 7 quarters since.
  • 153 funds tracked by Wall St. Rank held Septerna Inc as of Q2 2026.

Based on Driehaus Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.