DCM
SEPN

Driehaus Capital Management’s Septerna Inc SEPN Stock Holding History

Driehaus Capital Management’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$106M Sell
4,395,572
-413,898
-9% -$10.9M 0.78% 25
2025
Q4 		$134M Sell
4,809,470
-110,426
-2% -$2.64M 0.91% 16
2025
Q3 		$92.5M Buy
4,919,896
+239,465
+5% +$3.14M 0.66% 34
2025
Q2 		$49.5M Buy
4,680,431
+1,557,823
+50% +$12.8M 0.4% 82
2025
Q1 		$18.1M Buy
3,122,608
+533,055
+21% +$6.09M 0.17% 172
2024
Q4 		$59.3M Buy
+2,589,553
New +$61.2M 0.49% 65

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Driehaus Capital Management's SEPN Position: Q1 2026 in Review

Driehaus Capital Management reduced its Septerna Inc (SEPN) stake by 8.6% in Q1 2026, selling an estimated $10.9M and leaving 4,395,572 shares worth $106M. The position accounts for 0.78% of the portfolio, ranked #25.

Driehaus Capital Management first reported a position in SEPN in Q4 2024 and has held it in 6 quarters since. The position peaked at $134M in Q4 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • Driehaus Capital Management held 4,395,572 shares of Septerna Inc worth $106M as of Q1 2026.
  • Driehaus Capital Management sold 413,898 Septerna Inc shares in Q1 2026, an estimated $10.9M.
  • Septerna Inc made up 0.78% of Driehaus Capital Management's portfolio in Q1 2026, its #25 holding.
  • Driehaus Capital Management first reported a position in Septerna Inc in Q4 2024 and has held it in 6 quarters since.
  • Driehaus Capital Management's Septerna Inc position peaked at $134M in Q4 2025.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Driehaus Capital Management's 13F filing for Q1 2026, filed 15 May 2026.