TGV
SEPN

TRV GP VI’s Septerna Inc SEPN Stock Holding History

TRV GP VI’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$141M Hold
4,211,659
– – 60.72% 1
2026
Q1 		$101M Hold
4,211,659
– – 74.64% 1
2025
Q4 		$117M Hold
4,211,659
– – 79.05% 1
2025
Q3 		$79.2M Hold
4,211,659
– – 72.26% 1
2025
Q2 		$44.5M Hold
4,211,659
– – 69.32% 1
2025
Q1 		$24.4M Buy
4,211,659
+1,059,203
+34% +$12.1M 58.1% 1
2024
Q4 		$72.2M Buy
+3,152,456
New +$74.5M 61.75% 1

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.22B AUM 242.83% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

TRV GP VI's SEPN Position: Q2 2026 in Review

TRV GP VI held its Septerna Inc (SEPN) position steady in Q2 2026 at 4,211,659 shares worth $141M. The position accounts for 60.72% of the portfolio, ranked #1.

TRV GP VI first reported a position in SEPN in Q4 2024 and has held it in 7 quarters since. 154 funds tracked by Wall St. Rank hold SEPN as of Q2 2026.

  • TRV GP VI held 4,211,659 shares of Septerna Inc worth $141M as of Q2 2026.
  • TRV GP VI left its Septerna Inc share count unchanged in Q2 2026.
  • Septerna Inc made up 60.72% of TRV GP VI's portfolio in Q2 2026, its #1 holding.
  • TRV GP VI first reported a position in Septerna Inc in Q4 2024 and has held it in 7 quarters since.
  • 154 funds tracked by Wall St. Rank held Septerna Inc as of Q2 2026.

Based on TRV GP VI's 13F filing for Q2 2026, filed 10 Aug 2026.