TGV
SEPN

TRV GP VI’s Septerna Inc SEPN Stock Holding History

TRV GP VI’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$101M Hold
4,211,659
– – 74.64% 1
2025
Q4 		$117M Hold
4,211,659
– – 79.05% 1
2025
Q3 		$79.2M Hold
4,211,659
– – 72.26% 1
2025
Q2 		$44.5M Hold
4,211,659
– – 69.32% 1
2025
Q1 		$24.4M Buy
4,211,659
+1,059,203
+34% +$12.1M 58.1% 1
2024
Q4 		$72.2M Buy
+3,152,456
New +$74.5M 61.75% 1

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

TRV GP VI's SEPN Position: Q1 2026 in Review

TRV GP VI held its Septerna Inc (SEPN) position steady in Q1 2026 at 4,211,659 shares worth $101M. The position accounts for 74.64% of the portfolio, ranked #1.

TRV GP VI first reported a position in SEPN in Q4 2024 and has held it in 6 quarters since. The position peaked at $117M in Q4 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • TRV GP VI held 4,211,659 shares of Septerna Inc worth $101M as of Q1 2026.
  • TRV GP VI left its Septerna Inc share count unchanged in Q1 2026.
  • Septerna Inc made up 74.64% of TRV GP VI's portfolio in Q1 2026, its #1 holding.
  • TRV GP VI first reported a position in Septerna Inc in Q4 2024 and has held it in 6 quarters since.
  • TRV GP VI's Septerna Inc position peaked at $117M in Q4 2025.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on TRV GP VI's 13F filing for Q1 2026, filed 7 May 2026.