Janus Henderson Group
SEPN

Janus Henderson Group’s Septerna Inc SEPN Stock Holding History

Janus Henderson Group’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$21.3M Buy
+890,754
New +$23.4M 0.01% 591
2025
Q1 		– Sell
-1,096,302
Closed -$25.1M – 2564
2024
Q4 		$25.1M Buy
+1,096,302
New +$25.9M 0.01% 531

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Janus Henderson Group's SEPN Position: Q1 2026 in Review

Janus Henderson Group opened a new position in Septerna Inc (SEPN) in Q1 2026: 890,754 shares worth $21.3M. The stake represents 0.01% of the portfolio and ranks #591 among its holdings. This is a return to the name: Janus Henderson Group previously reported a position in SEPN as recently as Q4 2024.

Janus Henderson Group first reported a position in SEPN in Q4 2024 and has held it in 2 quarters since. The position peaked at $25.1M in Q4 2024. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • Janus Henderson Group held 890,754 shares of Septerna Inc worth $21.3M as of Q1 2026.
  • Septerna Inc was a new Janus Henderson Group position in Q1 2026.
  • Septerna Inc made up 0.01% of Janus Henderson Group's portfolio in Q1 2026, its #591 holding.
  • Janus Henderson Group first reported a position in Septerna Inc in Q4 2024 and has held it in 2 quarters since.
  • Janus Henderson Group's Septerna Inc position peaked at $25.1M in Q4 2024.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Janus Henderson Group's 13F filing for Q1 2026, filed 15 May 2026.