TGV
SEPN

TRV GP V’s Septerna Inc SEPN Stock Holding History

TRV GP V’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$149M Hold
6,215,591
– – 37.25% 2
2025
Q4 		$173M Hold
6,215,591
– – 40.38% 2
2025
Q3 		$117M Hold
6,215,591
– – 33.07% 2
2025
Q2 		$65.7M Hold
6,215,591
– – 39.66% 2
2025
Q1 		$36M Hold
6,215,591
– – 28.77% 2
2024
Q4 		$142M Buy
+6,215,591
New +$147M 48.42% 1

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

TRV GP V's SEPN Position: Q1 2026 in Review

TRV GP V held its Septerna Inc (SEPN) position steady in Q1 2026 at 6,215,591 shares worth $149M. The position accounts for 37.25% of the portfolio, ranked #2.

TRV GP V first reported a position in SEPN in Q4 2024 and has held it in 6 quarters since. The position peaked at $173M in Q4 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • TRV GP V held 6,215,591 shares of Septerna Inc worth $149M as of Q1 2026.
  • TRV GP V left its Septerna Inc share count unchanged in Q1 2026.
  • Septerna Inc made up 37.25% of TRV GP V's portfolio in Q1 2026, its #2 holding.
  • TRV GP V first reported a position in Septerna Inc in Q4 2024 and has held it in 6 quarters since.
  • TRV GP V's Septerna Inc position peaked at $173M in Q4 2025.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on TRV GP V's 13F filing for Q1 2026, filed 7 May 2026.