Millennium Management
SEPN

Millennium Management’s Septerna Inc SEPN Stock Holding History

Millennium Management’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$2.98M Buy
124,101
+16,638
+15% +$437K ﹤0.01% 3471
2025
Q4 		$3M Sell
107,463
-276,737
-72% -$6.61M ﹤0.01% 3561
2025
Q3 		$7.23M Buy
384,200
+332,256
+640% +$4.36M ﹤0.01% 2730
2025
Q2 		$549K Sell
51,944
-384,620
-88% -$3.17M ﹤0.01% 4843
2025
Q1 		$2.53M Buy
+436,564
New +$4.98M ﹤0.01% 3562

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Millennium Management's SEPN Position: Q1 2026 in Review

Millennium Management increased its Septerna Inc (SEPN) stake by 15% in Q1 2026, buying an estimated $437K and bringing the position to 124,101 shares worth $2.98M. The position accounts for ﹤0.01% of the portfolio, ranked #3471.

Millennium Management first reported a position in SEPN in Q1 2025 and has held it in 5 quarters since. The position peaked at $7.23M in Q3 2025. 124 funds tracked by Wall St. Rank hold SEPN as of Q1 2026.

  • Millennium Management held 124,101 shares of Septerna Inc worth $2.98M as of Q1 2026.
  • Millennium Management bought 16,638 Septerna Inc shares in Q1 2026, an estimated $437K.
  • Septerna Inc made up ﹤0.01% of Millennium Management's portfolio in Q1 2026, its #3471 holding.
  • Millennium Management first reported a position in Septerna Inc in Q1 2025 and has held it in 5 quarters since.
  • Millennium Management's Septerna Inc position peaked at $7.23M in Q3 2025.
  • 124 funds tracked by Wall St. Rank held Septerna Inc as of Q1 2026.

Based on Millennium Management's 13F filing for Q1 2026, filed 15 May 2026.