Millennium Management
SEPN

Millennium Management’s Septerna Inc SEPN Stock Holding History

Millennium Management’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$1.69M Sell
50,562
-73,539
-59% -$2.09M ﹤0.01% 3945
2026
Q1 		$2.98M Buy
124,101
+16,638
+15% +$437K ﹤0.01% 3471
2025
Q4 		$3M Sell
107,463
-276,737
-72% -$6.61M ﹤0.01% 3561
2025
Q3 		$7.23M Buy
384,200
+332,256
+640% +$4.36M ﹤0.01% 2730
2025
Q2 		$549K Sell
51,944
-384,620
-88% -$3.17M ﹤0.01% 4843
2025
Q1 		$2.53M Buy
+436,564
New +$4.98M ﹤0.01% 3562

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $232M AUM 247.08% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.22B AUM 242.83% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM

Millennium Management's SEPN Position: Q2 2026 in Review

Millennium Management reduced its Septerna Inc (SEPN) stake by 59% in Q2 2026, selling an estimated $2.09M and leaving 50,562 shares worth $1.69M. The position accounts for ﹤0.01% of the portfolio, ranked #3945.

Millennium Management first reported a position in SEPN in Q1 2025 and has held it in 6 quarters since. The position peaked at $7.23M in Q3 2025. 153 funds tracked by Wall St. Rank hold SEPN as of Q2 2026.

  • Millennium Management held 50,562 shares of Septerna Inc worth $1.69M as of Q2 2026.
  • Millennium Management sold 73,539 Septerna Inc shares in Q2 2026, an estimated $2.09M.
  • Septerna Inc made up ﹤0.01% of Millennium Management's portfolio in Q2 2026, its #3945 holding.
  • Millennium Management first reported a position in Septerna Inc in Q1 2025 and has held it in 6 quarters since.
  • Millennium Management's Septerna Inc position peaked at $7.23M in Q3 2025.
  • 153 funds tracked by Wall St. Rank held Septerna Inc as of Q2 2026.

Based on Millennium Management's 13F filing for Q2 2026, filed 14 Aug 2026.