CCM
SEPN

Catalio Capital Management’s Septerna Inc SEPN Stock Holding History

Catalio Capital Management’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$18M Buy
536,152
+241,792
+82% +$6.86M 3.37% 11
2026
Q1 		$7.07M Hold
294,360
– – 1.48% 25
2025
Q4 		$8.21M Hold
294,360
– – 1.45% 28
2025
Q3 		$5.54M Hold
294,360
– – 1.02% 27
2025
Q2 		$3.11M Sell
294,360
-729,885
-71% -$6.01M 0.65% 26
2025
Q1 		$5.93M Hold
1,024,245
– – 1.44% 19
2024
Q4 		$23.5M Buy
+1,024,245
New +$24.2M 5.13% 9

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $232M AUM 247.08% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.22B AUM 242.83% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $11.1B AUM 207.82% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM

Catalio Capital Management's SEPN Position: Q2 2026 in Review

Catalio Capital Management increased its Septerna Inc (SEPN) stake by 82% in Q2 2026, buying an estimated $6.86M and bringing the position to 536,152 shares worth $18M. The position accounts for 3.37% of the portfolio, ranked #11.

Catalio Capital Management first reported a position in SEPN in Q4 2024 and has held it in 7 quarters since. The position peaked at $23.5M in Q4 2024. 154 funds tracked by Wall St. Rank hold SEPN as of Q2 2026.

  • Catalio Capital Management held 536,152 shares of Septerna Inc worth $18M as of Q2 2026.
  • Catalio Capital Management bought 241,792 Septerna Inc shares in Q2 2026, an estimated $6.86M.
  • Septerna Inc made up 3.37% of Catalio Capital Management's portfolio in Q2 2026, its #11 holding.
  • Catalio Capital Management first reported a position in Septerna Inc in Q4 2024 and has held it in 7 quarters since.
  • Catalio Capital Management's Septerna Inc position peaked at $23.5M in Q4 2024.
  • 154 funds tracked by Wall St. Rank held Septerna Inc as of Q2 2026.

Based on Catalio Capital Management's 13F filing for Q2 2026, filed 14 Aug 2026.