Vanguard Group
SEPN

Vanguard Group’s Septerna Inc SEPN Stock Holding History

Vanguard Group’s Portfolio SEPN Stock Details SEPN Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		$42M Sell
1,508,195
-10,562
-0.7% -$252K ﹤0.01% 2264
2025
Q3 		$28.6M Buy
1,518,757
+104,394
+7% +$1.37M ﹤0.01% 2449
2025
Q2 		$14.9M Buy
1,414,363
+419,319
+42% +$3.45M ﹤0.01% 2701
2025
Q1 		$5.76M Buy
995,044
+10,012
+1% +$114K ﹤0.01% 3113
2024
Q4 		$22.6M Buy
+985,032
New +$23.3M ﹤0.01% 2531

Other funds holding SEPN

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
TGV
TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
TGV
TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return
SB
Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return
Goldman Sachs
Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return
SL
Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Vanguard Group's SEPN Position: Q4 2025 in Review

Vanguard Group reduced its Septerna Inc (SEPN) stake by 0.7% in Q4 2025, selling an estimated $252K and leaving 1,508,195 shares worth $42M. The position accounts for ﹤0.01% of the portfolio, ranked #2264.

Vanguard Group first reported a position in SEPN in Q4 2024 and has held it in 5 quarters since. 122 funds tracked by Wall St. Rank hold SEPN as of Q4 2025.

  • Vanguard Group held 1,508,195 shares of Septerna Inc worth $42M as of Q4 2025.
  • Vanguard Group sold 10,562 Septerna Inc shares in Q4 2025, an estimated $252K.
  • Septerna Inc made up ﹤0.01% of Vanguard Group's portfolio in Q4 2025, its #2264 holding.
  • Vanguard Group first reported a position in Septerna Inc in Q4 2024 and has held it in 5 quarters since.
  • 122 funds tracked by Wall St. Rank held Septerna Inc as of Q4 2025.

Based on Vanguard Group's 13F filing for Q4 2025, filed 29 Jan 2026.