Sio Capital Management’s Septerna Inc SEPN Stock Holding History

Sio Capital Management’s Portfolio SEPN Stock Details SEPN Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q4	–	Sell	-189,199	Closed	-$3.56M	–	77
2025 Q3	$3.56M	Sell	189,199 -395,236	-68%	-$5.19M	0.9%	29
2025 Q2	$6.18M	Sell	584,435 -204,235	-26%	-$1.68M	2.36%	16
2025 Q1	$4.57M	Buy	788,670 +516,983	+190%	+$5.9M	1.36%	18
2024 Q4	$6.22M	Buy	+271,687	New	+$6.42M	1.75%	21

Other funds holding SEPN

RCM

RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return

TGV

TRV GP V Boston, Massachusetts $498M AUM 267.53% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

TGV

TRV GP VI Boston, Massachusetts $232M AUM 247.08% 1-Year Est. Return

Samsara BioCapital Palo Alto, California $1.22B AUM 242.83% 1-Year Est. Return

Goldman Sachs New York $1.15T AUM 47.82% 1-Year Est. Return

Siren LLC Greenwich, Connecticut $4.94B AUM 244.43% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

BVF Inc San Francisco, California $3.91B AUM 304.52% 1-Year Est. Return

Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return

Sio Capital Management's SEPN Position: Q4 2025 in Review

Sio Capital Management sold out of Septerna Inc (SEPN) in Q4 2025, closing a stake of 189,199 shares — an estimated $3.56M sold.

Sio Capital Management first reported a position in SEPN in Q4 2024 and held it in 4 quarters. The position peaked at $6.22M in Q4 2024. 122 funds tracked by Wall St. Rank hold SEPN as of Q4 2025.

Sio Capital Management reported no remaining Septerna Inc position as of Q4 2025 after selling out during the quarter.
Sio Capital Management sold 189,199 Septerna Inc shares in Q4 2025, an estimated $3.56M.
Sio Capital Management first reported a position in Septerna Inc in Q4 2024 and held it in 4 quarters.
Sio Capital Management's Septerna Inc position peaked at $6.22M in Q4 2024.
122 funds tracked by Wall St. Rank held Septerna Inc as of Q4 2025.

Based on Sio Capital Management's 13F filing for Q4 2025, filed 17 Feb 2026.