Sio Capital Management’s Septerna Inc SEPN Stock Holding History

Sio Capital Management’s Portfolio SEPN Stock Details SEPN Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q4	–	Sell	-189,199	Closed	-$3.56M	–	80
2025 Q3	$3.56M	Sell	189,199 -395,236	-68%	-$5.19M	0.9%	29
2025 Q2	$6.18M	Sell	584,435 -204,235	-26%	-$1.68M	2.48%	16
2025 Q1	$4.57M	Buy	788,670 +516,983	+190%	+$5.9M	1.38%	18
2024 Q4	$6.22M	Buy	+271,687	New	+$6.42M	1.75%	21

Other funds holding SEPN

RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return

TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return

Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return

Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return

Goldman Sachs New York $761B AUM 31.28% 1-Year Est. Return

Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return

BlackRock New York $5.7T AUM 30.48% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return