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Siren LLC’s Edgewise Therapeutics EWTX Stock Holding History

Siren LLC’s Portfolio EWTX Stock Details EWTX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$129M Sell
3,184,629
-1,245,634
-28% -$42.9M 2.62% 10
2026
Q1 		$140M Sell
4,430,263
-99,727
-2% -$2.88M 3.87% 4
2025
Q4 		$112M Buy
4,529,990
+632,891
+16% +$12.7M 3.35% 4
2025
Q3 		$63.2M Buy
3,897,099
+736,801
+23% +$10.5M 2.47% 8
2025
Q2 		$41.4M Buy
3,160,298
+1,463,854
+86% +$21.1M 2.14% 13
2025
Q1 		$37.3M Buy
1,696,444
+962,101
+131% +$25.2M 2.11% 14
2024
Q4 		$19.6M Buy
734,343
+330,230
+82% +$10.5M 0.87% 32
2024
Q3 		$10.8M Buy
+404,113
New +$8.04M 0.54% 41

Other funds holding EWTX

O
OrbiMed New York $5.4B AUM 163.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM
Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
NHAS
Novo Holdings A/S Hellerup, Denmark $1.72B AUM 106.92% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

Siren LLC's EWTX Position: Q2 2026 in Review

Siren LLC reduced its Edgewise Therapeutics (EWTX) stake by 28% in Q2 2026, selling an estimated $42.9M and leaving 3,184,629 shares worth $129M. The position accounts for 2.62% of the portfolio, ranked #10.

Siren LLC first reported a position in EWTX in Q3 2024 and has held it in 8 quarters since. The position peaked at $140M in Q1 2026. 227 funds tracked by Wall St. Rank hold EWTX as of Q2 2026.

  • Siren LLC held 3,184,629 shares of Edgewise Therapeutics worth $129M as of Q2 2026.
  • Siren LLC sold 1,245,634 Edgewise Therapeutics shares in Q2 2026, an estimated $42.9M.
  • Edgewise Therapeutics made up 2.62% of Siren LLC's portfolio in Q2 2026, its #10 holding.
  • Siren LLC first reported a position in Edgewise Therapeutics in Q3 2024 and has held it in 8 quarters since.
  • Siren LLC's Edgewise Therapeutics position peaked at $140M in Q1 2026.
  • 227 funds tracked by Wall St. Rank held Edgewise Therapeutics as of Q2 2026.

Based on Siren LLC's 13F filing for Q2 2026, filed 13 Aug 2026.