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Edgewise Therapeutics
EWTX

214 hedge funds and large institutions have $3.72B invested in Edgewise Therapeutics in 2026 Q1 according to their latest regulatory filings, with 44 funds opening new positions, 65 increasing their positions, 66 reducing their positions, and 24 closing their positions.

New
Increased
Maintained
Reduced
Closed

83% more first-time investments, than exits

New positions opened: 44 | Existing positions closed: 24

69% more call options, than puts

Call options by funds: $18.7M | Put options by funds: $11.1M

23% more capital invested

Capital invested by funds: $3.02B → $3.72B (+$699M)

10% more funds holding in top 10

Funds holding in top 10: 10 → 11 (+1)

8% more funds holding

Funds holding: 199 → 214 (+15)

2% less repeat investments, than reductions

Existing positions increased: 65 | Existing positions reduced: 66

4.57% less ownership

Funds ownership: 115.07% → 110.5% (-4.6%)

Holders
214
Holders Change
+15
Holders Change %
+7.54%
% of All Funds
2.63%
Holding in Top 10
11
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+10%
% of All Funds
0.14%
New
44
Increased
65
Reduced
66
Closed
24
Calls
$18.7M
Puts
$11.1M
Net Calls
+$7.66M
Net Calls Change
+$6.35M

Top Buyers

1
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$38.9M
2
PBA
Paradigm Biocapital Advisors
New York
+$23.8M
3
AllianceBernstein
AllianceBernstein
Tennessee
+$19.8M
4
SCM
Soleus Capital Management
Connecticut
+$15.6M
5
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
+$15.3M

Top Sellers

1
B
Braidwell
Connecticut
-$82.6M
2
UBS Group
UBS Group
Switzerland
-$23.2M
3
Morgan Stanley
Morgan Stanley
New York
-$19.2M
4
DM
Deerfield Management
New York
-$19M
5
FLAM
First Light Asset Management
Minnesota
-$16.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
O
1
OrbiMed
New York
$489M – – –
RCM
2
RA Capital Management
Massachusetts
$328M – – –
PBA
3
Paradigm Biocapital Advisors
New York
$232M +$23.8M +823,828 +13%
BBA
4
Baker Bros. Advisors
New York
$207M – – –
BlackRock
5
BlackRock
New York
$204M -$4.54M -157,585 -2%
Janus Henderson Group
6
Janus Henderson Group
United Kingdom
$186M +$38.9M +1,348,706 +30%
NHAS
7
Novo Holdings A/S
Denmark
$169M – – –
DCM
8
Driehaus Capital Management
Illinois
$141M +$8.27M +286,749 +7%
SL
9
Siren LLC
Connecticut
$140M -$2.88M -99,727 -2%
PA
10
Perceptive Advisors
New York
$139M -$980K -34,000 -0.8%
VCM
11
Vanguard Capital Management
Pennsylvania
$119M +$109M +3,788,161 New
CAM
12
Cormorant Asset Management
Massachusetts
$103M -$721K -25,000 -0.8%
B
13
Braidwell
Connecticut
$73.9M -$82.6M -2,863,248 -55%
Morgan Stanley
14
Morgan Stanley
New York
$70.7M -$19.2M -664,853 -23%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$56.4M +$1.26M +43,597 +2%
State Street
16
State Street
Massachusetts
$54.1M -$15K -520 -0%
MB
17
MPM BioImpact
Massachusetts
$52.3M +$157K +5,440 +0.3%
IHAM
18
Integral Health Asset Management
New York
$50.4M +$2.88M +100,000 +7%
BG
19
Bellevue Group
Switzerland
$48.1M – – –
SCM
20
Soleus Capital Management
Connecticut
$45.7M +$15.6M +539,915 +59%
AllianceBernstein
21
AllianceBernstein
Tennessee
$42.7M +$19.8M +685,999 +66%
Bank of America
22
Bank of America
North Carolina
$41.8M -$4.25M -147,437 -10%
UBS Group
23
UBS Group
Switzerland
$41.3M -$23.2M -805,948 -38%
Dimensional Fund Advisors
24
Dimensional Fund Advisors
Texas
$38.4M +$175K +6,060 +0.5%
American Century Companies
25
American Century Companies
Missouri
$36.1M -$1.13M -39,291 -3%
1
2 3 4 5

EWTX Hedge Fund Activity: Q1 2026 in Review

214 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Edgewise Therapeutics (EWTX) for Q1 2026, worth a combined $3.72B — up 23% from $3.02B a quarter earlier.

Buyers outnumbered sellers: 44 funds opened new EWTX positions and 24 closed out — a net gain of 20 holders — while 65 added to existing stakes and 66 trimmed.

The largest buyer was Janus Henderson Group, adding an estimated $38.9M. The largest seller was Braidwell, cutting an estimated $82.6M.

  • 214 institutional investors held Edgewise Therapeutics (EWTX) as of Q1 2026, up from 199 in Q4 2025.
  • Funds reported $3.72B of Edgewise Therapeutics stock for Q1 2026, up 23% quarter-over-quarter.
  • 44 funds opened new Edgewise Therapeutics positions in Q1 2026 and 24 closed out, a net change of +20 holders.
  • The largest Edgewise Therapeutics buyer in Q1 2026 was Janus Henderson Group, an estimated $38.9M added.
  • The largest Edgewise Therapeutics seller in Q1 2026 was Braidwell, an estimated $82.6M sold.

Based on aggregated 13F filings for Q1 2026.