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Edgewise Therapeutics

192 hedge funds and large institutions have $2.32B invested in Edgewise Therapeutics in 2025 Q1 according to their latest regulatory filings, with 32 funds opening new positions, 68 increasing their positions, 63 reducing their positions, and 38 closing their positions.

New
Increased
Maintained
Reduced
Closed

88% more call options, than puts

Call options by funds: $61.6M | Put options by funds: $32.7M

11% more funds holding in top 10

Funds holding in top 10: 910 (+1)

6.09% more ownership

Funds ownership: 104.55%110.64% (+6.1%)

8% more repeat investments, than reductions

Existing positions increased: 68 | Existing positions reduced: 63

4% less funds holding

Funds holding: 200192 (-8)

12% less capital invested

Capital invested by funds: $2.64B → $2.32B (-$321M)

16% less first-time investments, than exits

New positions opened: 32 | Existing positions closed: 38

Holders
192
Holders Change
-8
Holders Change %
-4%
% of All Funds
2.57%
Holding in Top 10
10
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+11.11%
% of All Funds
0.13%
New
32
Increased
68
Reduced
63
Closed
38
Calls
$61.6M
Puts
$32.7M
Net Calls
+$28.9M
Net Calls Change
+$15.4M
Name Holding Trade Value Shares
Change
Change in
Stake
O
1
OrbiMed
New York
$330M
RCM
2
RA Capital Management
Massachusetts
$196M
PA
3
Perceptive Advisors
New York
$144M +$101M +3,861,791 +144%
BlackRock
4
BlackRock
New York
$143M +$157K +5,993 +0.1%
BBA
5
Baker Bros. Advisors
New York
$135M
Janus Henderson Group
6
Janus Henderson Group
United Kingdom
$123M +$7.82M +298,214 +6%
NHAS
7
Novo Holdings A/S
Denmark
$118M +$9.18M +350,000 +7%
PBA
8
Paradigm Biocapital Advisors
New York
$96.7M -$2.61M -99,373 -2%
Vanguard Group
9
Vanguard Group
Pennsylvania
$94.5M -$4.52M -172,445 -4%
CAM
10
Cormorant Asset Management
Massachusetts
$90.2M +$18.2M +695,458 +20%
B
11
Braidwell
Connecticut
$54.1M +$3.32M +126,612 +5%
DM
12
Deerfield Management
New York
$45.7M
FLAM
13
First Light Asset Management
Minnesota
$40.8M +$28.1M +1,071,651 +137%
State Street
14
State Street
Massachusetts
$37.8M +$57.2K +2,179 +0.1%
SL
15
Siren LLC
Connecticut
$37.3M +$25.2M +962,101 +131%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$36.4M +$1.45M +55,093 +3%
BG
17
Bellevue Group
Switzerland
$31.4M
DTC
18
Deep Track Capital
Connecticut
$30.8M +$18.1M +689,579 +97%
DCM
19
Driehaus Capital Management
Illinois
$30.3M -$3.1M -118,049 -8%
MB
20
MPM BioImpact
Massachusetts
$24.3M +$685K +26,128 +2%
WP
21
Woodline Partners
California
$24.1M +$13.9M +529,591 +93%
NLVP
22
New Leaf Venture Partners
New York
$22.7M
Artisan Partners
23
Artisan Partners
Wisconsin
$20.2M -$4.05M -154,374 -14%
American Century Companies
24
American Century Companies
Missouri
$17.2M +$247K +9,413 +1%
Bank of America
25
Bank of America
North Carolina
$15.3M +$17M +646,519 +1,322%

EWTX Hedge Fund Activity: Q1 2025 in Review

192 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Edgewise Therapeutics (EWTX) for Q1 2025, worth a combined $2.32B — down 12% from $2.64B a quarter earlier.

Sellers outnumbered buyers: 38 funds closed out of EWTX and 32 opened new positions — a net loss of 6 holders — while 63 trimmed existing stakes and 68 added.

The largest buyer was Perceptive Advisors, adding an estimated $101M. The largest seller was Frazier Life Sciences Management, exiting entirely with an estimated $33.9M sold.

  • 192 institutional investors held Edgewise Therapeutics (EWTX) as of Q1 2025, down from 200 in Q4 2024.
  • Funds reported $2.32B of Edgewise Therapeutics stock for Q1 2025, down 12% quarter-over-quarter.
  • 32 funds opened new Edgewise Therapeutics positions in Q1 2025 and 38 closed out, a net change of -6 holders.
  • The largest Edgewise Therapeutics buyer in Q1 2025 was Perceptive Advisors, an estimated $101M added.
  • The largest Edgewise Therapeutics seller in Q1 2025 was Frazier Life Sciences Management, an estimated $33.9M sold.

Based on aggregated 13F filings for Q1 2025.