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Edgewise Therapeutics

223 hedge funds and large institutions have $4.82B invested in Edgewise Therapeutics in 2026 Q2 according to their latest regulatory filings, with 41 funds opening new positions, 83 increasing their positions, 72 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

94% more call options, than puts

Call options by funds: $17.6M | Put options by funds: $9.08M

58% more first-time investments, than exits

New positions opened: 41 | Existing positions closed: 26

29% more capital invested

Capital invested by funds: $3.72B → $4.82B (+$1.1B)

18% more funds holding in top 10

Funds holding in top 10: 1113 (+2)

15% more repeat investments, than reductions

Existing positions increased: 83 | Existing positions reduced: 72

4% more funds holding

Funds holding: 214223 (+9)

0.2% more ownership

Funds ownership: 110.5%110.7% (+0.2%)

Holders
223
Holders Change
+9
Holders Change %
+4.21%
% of All Funds
2.7%
Holding in Top 10
13
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+18.18%
% of All Funds
0.16%
New
41
Increased
83
Reduced
72
Closed
26
Calls
$17.6M
Puts
$9.08M
Net Calls
+$8.56M
Net Calls Change
+$900K
Name Holding Trade Value Shares
Change
Change in
Stake
O
1
OrbiMed
New York
$631M
PBA
2
Paradigm Biocapital Advisors
New York
$415M +$98.3M +2,850,417 +39%
RCM
3
RA Capital Management
Massachusetts
$341M -$70.2M -2,035,707 -20%
BlackRock
4
BlackRock
New York
$268M +$4.6M +133,345 +2%
JT
5
Jupiter Topco
New York
$247M +$209M +6,075,331 New
Fidelity Investments
6
Fidelity Investments
Massachusetts
$223M +$154M +4,472,083 +440%
NHAS
7
Novo Holdings A/S
Denmark
$217M
DCM
8
Driehaus Capital Management
Illinois
$192M +$8.64M +250,681 +6%
PA
9
Perceptive Advisors
New York
$178M -$1.72M -50,000 -1%
Vanguard Capital Management
10
Vanguard Capital Management
Pennsylvania
$157M +$2.5M +72,509 +2%
BBA
11
Baker Bros. Advisors
New York
$150M -$99.1M -2,874,221 -44%
SL
12
Siren LLC
Connecticut
$129M -$42.9M -1,245,634 -28%
CAM
13
Cormorant Asset Management
Massachusetts
$102M -$25.9M -750,000 -23%
Geode Capital Management
14
Geode Capital Management
Massachusetts
$88.3M +$13.2M +384,232 +21%
IHAM
15
Integral Health Asset Management
New York
$81.3M +$13.8M +400,000 +25%
B
16
Braidwell
Connecticut
$81.1M -$12.1M -350,618 -15%
Morgan Stanley
17
Morgan Stanley
New York
$79.2M -$10.3M -297,431 -13%
State Street
18
State Street
Massachusetts
$74.3M +$3.83M +111,104 +6%
AllianceBernstein
19
AllianceBernstein
Tennessee
$66.7M +$13.7M +396,855 +23%
MB
20
MPM BioImpact
Massachusetts
$65.9M -$1.38M -39,916 -2%
Bank of America
21
Bank of America
North Carolina
$63.3M +$7.96M +230,900 +17%
Qube Research & Technologies (QRT)
22
Qube Research & Technologies (QRT)
United Kingdom
$50.9M +$14.7M +426,597 +52%
Dimensional Fund Advisors
23
Dimensional Fund Advisors
Texas
$46.3M -$2.76M -79,991 -7%
American Century Companies
24
American Century Companies
Missouri
$45.8M -$693K -20,098 -2%
FLAM
25
First Light Asset Management
Minnesota
$44.5M +$3.22M +93,325 +9%

EWTX Hedge Fund Activity: Q2 2026 in Review

223 of the 8,274 institutional investors tracked by Wall St. Rank reported a position in Edgewise Therapeutics (EWTX) for Q2 2026, worth a combined $4.82B — up 29% from $3.72B a quarter earlier.

Buyers outnumbered sellers: 41 funds opened new EWTX positions and 26 closed out — a net gain of 15 holders — while 83 added to existing stakes and 72 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $154M. The largest seller was Baker Bros. Advisors, cutting an estimated $99.1M.

  • 223 institutional investors held Edgewise Therapeutics (EWTX) as of Q2 2026, up from 214 in Q1 2026.
  • Funds reported $4.82B of Edgewise Therapeutics stock for Q2 2026, up 29% quarter-over-quarter.
  • 41 funds opened new Edgewise Therapeutics positions in Q2 2026 and 26 closed out, a net change of +15 holders.
  • The largest Edgewise Therapeutics buyer in Q2 2026 was Fidelity Investments, an estimated $154M added.
  • The largest Edgewise Therapeutics seller in Q2 2026 was Baker Bros. Advisors, an estimated $99.1M sold.

Based on aggregated 13F filings for Q2 2026.