SL

Siren LLC Portfolio holdings

AUM $1.93B
1-Year Est. Return 118.08%
This Quarter Est. Return
1 Year Est. Return
+118.08%
3 Year Est. Return
5 Year Est. Return
10 Year Est. Return
AUM
$1.77B
AUM Growth
-$491M
Cap. Flow
Cap. Flow %
Top 10 Hldgs %
Holding
140
New
Increased
Reduced
Closed

Top Buys

1
+$64.3M
2
+$53.2M
3
+$26.8M
4
EWTX icon
Edgewise Therapeutics
EWTX
+$21.2M
5
RYTM icon
Rhythm Pharmaceuticals
RYTM
+$14.7M

Top Sells

1
+$70.8M
2
+$49.8M
3
+$42.2M
4
MDGL icon
Madrigal Pharmaceuticals
MDGL
+$38.9M
5
CYTK icon
Cytokinetics
CYTK
+$18.9M

Sector Composition

1 Healthcare 89.75%
2 Technology 5.2%
3 Communication Services 2.41%
4 Consumer Discretionary 1.21%
5 Real Estate 0.81%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SRRK icon
1
Scholar Rock
SRRK
$2.87B
$297M 16.78%
9,250,005
ONC
2
BeOne Medicines Ltd
ONC
$34.8B
$136M 7.66%
498,689
-155,032
KYMR icon
3
Kymera Therapeutics
KYMR
$4.43B
$88.7M 5%
3,240,313
+270,580
BPMC
4
DELISTED
Blueprint Medicines
BPMC
$64.3M 3.63%
+726,167
CRNX icon
5
Crinetics Pharmaceuticals
CRNX
$3.96B
$56.6M 3.19%
1,688,611
+78,959
APLS icon
6
Apellis Pharmaceuticals
APLS
$3.8B
$56.4M 3.18%
2,578,396
-237,862
IRON icon
7
Disc Medicine
IRON
$3.28B
$53.2M 3%
+1,071,865
SLNO icon
8
Soleno Therapeutics
SLNO
$3.65B
$52M 2.93%
727,337
+375,519
ASND icon
9
Ascendis Pharma
ASND
$12.5B
$44.8M 2.53%
287,366
-9,955
MRUS icon
10
Merus
MRUS
$7.19B
$43.9M 2.48%
1,043,467
+259,055
BCAX
11
Bicara Therapeutics
BCAX
$933M
$42.6M 2.4%
3,267,083
-5,744
CNTA
12
Centessa Pharmaceuticals
CNTA
$3.35B
$42.6M 2.4%
2,960,029
-44,648
NAMS icon
13
NewAmsterdam Pharma
NAMS
$4.07B
$39.1M 2.21%
1,912,030
-183,608
EWTX icon
14
Edgewise Therapeutics
EWTX
$1.73B
$37.3M 2.11%
1,696,444
+962,101
ARWR icon
15
Arrowhead Research
ARWR
$5.47B
$34M 1.92%
2,669,880
-231,801
RNA icon
16
Avidity Biosciences
RNA
$10.2B
$32.8M 1.85%
1,110,610
-16,685
WVE icon
17
Wave Life Sciences
WVE
$1.21B
$29.9M 1.68%
3,696,322
-54,169
TBLA icon
18
Taboola.com
TBLA
$1.05B
$29.4M 1.66%
9,969,495
DYN icon
19
Dyne Therapeutics
DYN
$3.46B
$28.4M 1.6%
2,717,987
+1,370,531
SLDB icon
20
Solid Biosciences
SLDB
$461M
$27.4M 1.55%
7,415,905
+3,666,864
XENE icon
21
Xenon Pharmaceuticals
XENE
$3.28B
$24.6M 1.39%
732,761
-11,008
APGE icon
22
Apogee Therapeutics
APGE
$3.81B
$22.2M 1.25%
594,994
-152,331
RVMD icon
23
Revolution Medicines
RVMD
$10.9B
$19.9M 1.12%
563,755
-7,793
TRVI icon
24
Trevi Therapeutics
TRVI
$1.28B
$18M 1.02%
2,863,793
-42,267
VERA icon
25
Vera Therapeutics
VERA
$1.91B
$17.9M 1.01%
747,216
-11,249
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