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Siren LLC Portfolio holdings

AUM $3.61B
1-Year Est. Return 203.3%
This Fund
S&P 500
This Quarter Est. Return
+28.71%
1 Year Est. Return
+203.3%
3 Year Est. Return
–
5 Year Est. Return
–
10 Year Est. Return
–
AUM
$3.61B
AUM Growth
+$255M
Cap. Flow
+$47.3M
Cap. Flow %
1.31%
Top 10 Hldgs %
49.77%
Holding
131
New
18
Increased
36
Reduced
18
Closed
31

Top Buys

Rank Stock Value
1
MANE
Veradermics Inc
MANE
+$75.9M
2
CYTK icon
Cytokinetics
CYTK
+$39M
3
OLMA icon
Olema Pharmaceuticals
OLMA
+$32.4M
4
ERAS icon
Erasca
ERAS
+$29.4M
5
XENE icon
Xenon Pharmaceuticals
XENE
+$23.3M

Top Sells

Rank Stock Value
1
CNTA
Centessa Pharmaceuticals
CNTA
+$76.1M
2
APLS
Apellis Pharmaceuticals
APLS
+$64.8M
3
ASND icon
Ascendis Pharma A/S
ASND
+$50.3M
4
RAPT
RAPT Therapeutics
RAPT
+$46.6M
5
ZYME icon
Zymeworks
ZYME
+$44.2M

Sector Composition

Rank Sector Weight
1 Healthcare 93.63%
2 Technology 3.69%
3 Communication Services 1.71%
4 Consumer Discretionary 0.77%
5 Industrials 0.08%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
IVVD icon
76
Invivyd
IVVD
$178M
$5.2M 0.14%
4,000,000
– –
MSLE
77
Satellos Bioscience
MSLE
$196M
$5.02M 0.14%
+892,074
New +$8.76M
IONQ icon
78
IonQ
IONQ
$13.4B
$4.9M 0.14%
170,000
– –
AVGO icon
79
Broadcom
AVGO
$1.82T
$4.64M 0.13%
15,000
+8,000
+114% +$2.63M
AGMB
80
AgomAb Therapeutics NV
AGMB
$614M
$4.31M 0.12%
+411,250
New +$5.82M
CLBT icon
81
Cellebrite
CLBT
$3.65B
$4.29M 0.12%
311,544
+161,544
+108% +$2.43M
SEER icon
82
Seer Inc
SEER
$109M
$4.13M 0.11%
2,458,673
-1,541,327
-39% -$2.85M
KRRO icon
83
Korro Bio
KRRO
$154M
$3.94M 0.11%
347,718
– –
AGEN
84
Agenus
AGEN
$255M
$3.55M 0.1%
1,064,250
– –
FHTX icon
85
Foghorn Therapeutics
FHTX
$305M
$3.45M 0.1%
720,720
– –
FPS
86
Forgent Power Solutions
FPS
$9.41B
$2.93M 0.08%
+100,000
New +$3.33M
KLRS
87
Kalaris Therapeutics
KLRS
$84.5M
$2.51M 0.07%
435,798
– –
GTLB icon
88
GitLab
GTLB
$5.55B
$2.16M 0.06%
100,000
+1,000
+1% +$29.2K
MU icon
89
Micron Technology
MU
$1.02T
$2.03M 0.06%
+6,000
New +$2.35M
MNDY icon
90
monday.com
MNDY
$3.47B
$1.73M 0.05%
25,000
+8,000
+47% +$768K
GOSS icon
91
Gossamer Bio
GOSS
$94.9M
$1.71M 0.05%
5,208,968
– –
AS icon
92
Amer Sports
AS
$20.5B
$1.65M 0.05%
+50,000
New +$1.83M
BEKE icon
93
KE Holdings
BEKE
$17.4B
$1.5M 0.04%
100,000
-45,000
-31% -$772K
IREN icon
94
Iris Energy
IREN
$13B
$1.48M 0.04%
43,100
– –
RANI icon
95
Rani Therapeutics
RANI
$90.5M
$1.47M 0.04%
2,000,000
– –
AEVA
96
Aeva Technologies
AEVA
$1.06B
$1.45M 0.04%
+110,000
New +$1.63M
MDLN
97
Medline Inc
MDLN
$33.6B
$1.11M 0.03%
25,000
-50,000
-67% -$2.21M
FIG
98
Figma
FIG
$12.1B
$1.06M 0.03%
50,000
+25,000
+100% +$686K
PRMB
99
Primo Brands
PRMB
$8.29B
$942K 0.03%
50,000
-25,000
-33% -$483K
NU icon
100
Nu Holdings
NU
$70.2B
$359K 0.01%
+25,000
New +$405K
2 3
4
5 6

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Siren LLC's Q1 2026 Portfolio in Review

As of Q1 2026, Siren LLC held 131 positions worth $3.61B, up 7.6% from $3.35B the previous quarter. Its ten largest holdings account for 50% of the portfolio.

Siren LLC's Q1 2026 filing shows 18 new, 36 increased, 18 reduced and 31 closed positions. Its largest new stake was Veradermics Inc: 1,505,374 shares worth $95.1M. The largest sale was Centessa Pharmaceuticals, an estimated $76.1M.

By sector, the portfolio is most concentrated in Healthcare at 94% of assets, up from 93% a quarter earlier, followed by Technology and Communication Services.

  • Siren LLC's largest Q1 2026 buy was Veradermics Inc: 1,505,374 shares worth $95.1M.
  • Siren LLC added most to Olema Pharmaceuticals in Q1 2026, an estimated $32.4M increase.
  • Siren LLC's biggest Q1 2026 reduction was Centessa Pharmaceuticals, cutting an estimated $76.1M.
  • Siren LLC fully exited Apellis Pharmaceuticals in Q1 2026, selling an estimated $64.8M.
  • Siren LLC's ten largest holdings make up 50% of its $3.61B portfolio in Q1 2026.
  • Siren LLC opened 18 new positions and closed 31 in Q1 2026.
  • Siren LLC's portfolio value rose 7.6% quarter-over-quarter to $3.61B.

Based on Siren LLC's 13F filing for Q1 2026, filed 14 May 2026.