XT
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XTX Topco’s Spyre Therapeutics SYRE Stock Holding History

XTX Topco’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$4.48M Buy
50,483
+26,048
+107% +$1.9M 0.06% 447
2026
Q1 		$1.23M Buy
+24,435
New +$921K 0.02% 1238
2025
Q2 		– Sell
-28,499
Closed -$460K – 3146
2025
Q1 		$460K Buy
+28,499
New +$593K 0.02% 1098

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

XTX Topco's SYRE Position: Q2 2026 in Review

XTX Topco increased its Spyre Therapeutics (SYRE) stake by 107% in Q2 2026, buying an estimated $1.9M and bringing the position to 50,483 shares worth $4.48M. The position accounts for 0.06% of the portfolio, ranked #447.

XTX Topco first reported a position in SYRE in Q1 2025 and has held it in 3 quarters since. 265 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • XTX Topco held 50,483 shares of Spyre Therapeutics worth $4.48M as of Q2 2026.
  • XTX Topco bought 26,048 Spyre Therapeutics shares in Q2 2026, an estimated $1.9M.
  • Spyre Therapeutics made up 0.06% of XTX Topco's portfolio in Q2 2026, its #447 holding.
  • XTX Topco first reported a position in Spyre Therapeutics in Q1 2025 and has held it in 3 quarters since.
  • 265 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on XTX Topco's 13F filing for Q2 2026, filed 14 Aug 2026.