California State Teachers Retirement System (CalSTRS)
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California State Teachers Retirement System (CalSTRS)’s Spyre Therapeutics SYRE Stock Holding History

California State Teachers Retirement System (CalSTRS)’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$5.74M Buy
64,687
+5,445
+9% +$397K 0.01% 993
2026
Q1 		$2.99M Buy
59,242
+11,204
+23% +$422K ﹤0.01% 1317
2025
Q4 		$1.57M Buy
48,038
+14,835
+45% +$388K ﹤0.01% 1555
2025
Q3 		$556K Buy
33,203
+2
+0% +$33 ﹤0.01% 2046
2025
Q2 		$497K Buy
33,201
+603
+2% +$8.92K ﹤0.01% 2056
2025
Q1 		$526K Hold
32,598
– – ﹤0.01% 2031
2024
Q4 		$759K Buy
32,598
+7,923
+32% +$232K ﹤0.01% 1920
2024
Q3 		$726K Buy
24,675
+5,570
+29% +$155K ﹤0.01% 1947
2024
Q2 		$449K Buy
19,105
+1,302
+7% +$43.9K ﹤0.01% 2141
2024
Q1 		$675K Buy
+17,803
New +$516K ﹤0.01% 2011
2022
Q2 		– Sell
-688
Closed -$40K – 3294
2022
Q1 		$40K Sell
688
-165
-19% -$13.9K ﹤0.01% 3083
2021
Q4 		$101K Sell
853
-15
-2% -$2.37K ﹤0.01% 2998
2021
Q3 		$172K Sell
868
-1,366
-61% -$239K ﹤0.01% 2787
2021
Q2 		$389K Sell
2,234
-497
-18% -$90.3K ﹤0.01% 2779
2021
Q1 		$541K Hold
2,731
– – ﹤0.01% 2486
2020
Q4 		$537K Buy
2,731
+198
+8% +$41K ﹤0.01% 2393
2020
Q3 		$449K Hold
2,533
– – ﹤0.01% 2329
2020
Q2 		$586K Buy
2,533
+903
+55% +$172K ﹤0.01% 2168
2020
Q1 		$190K Buy
1,630
+19
+1% +$3.23K ﹤0.01% 2578
2019
Q4 		$308K Hold
1,611
– – ﹤0.01% 2605
2019
Q3 		$310K Hold
1,611
– – ﹤0.01% 2580
2019
Q2 		$276K Buy
1,611
+428
+36% +$74K ﹤0.01% 2705
2019
Q1 		$238K Buy
1,183
+151
+15% +$31.5K ﹤0.01% 2698
2018
Q4 		$193K Buy
1,032
+34
+3% +$7.21K ﹤0.01% 2769
2018
Q3 		$239K Hold
998
– – ﹤0.01% 2818
2018
Q2 		$264K Buy
+998
New +$246K ﹤0.01% 2790

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

California State Teachers Retirement System (CalSTRS)'s SYRE Position: Q2 2026 in Review

California State Teachers Retirement System (CalSTRS) increased its Spyre Therapeutics (SYRE) stake by 9.2% in Q2 2026, buying an estimated $397K and bringing the position to 64,687 shares worth $5.74M. The position accounts for 0.01% of the portfolio, ranked #993.

California State Teachers Retirement System (CalSTRS) first reported a position in SYRE in Q2 2018 and has held it in 26 quarters since. 265 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • California State Teachers Retirement System (CalSTRS) held 64,687 shares of Spyre Therapeutics worth $5.74M as of Q2 2026.
  • California State Teachers Retirement System (CalSTRS) bought 5,445 Spyre Therapeutics shares in Q2 2026, an estimated $397K.
  • Spyre Therapeutics made up 0.01% of California State Teachers Retirement System (CalSTRS)'s portfolio in Q2 2026, its #993 holding.
  • California State Teachers Retirement System (CalSTRS) first reported a position in Spyre Therapeutics in Q2 2018 and has held it in 26 quarters since.
  • 265 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on California State Teachers Retirement System (CalSTRS)'s 13F filing for Q2 2026, filed 24 Aug 2026.