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Karyopharm Therapeutics
KPTI

Overview Fund Activity

168 hedge funds and large institutions have $987M invested in Karyopharm Therapeutics in 2020 Q4 according to their latest regulatory filings, with 32 funds opening new positions, 61 increasing their positions, 44 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
168
Holders Change
+11
Holders Change %
+7.01%
% of All Funds
2.98%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
32
Increased
61
Reduced
44
Closed
21
Calls
$11.2M
Puts
$7.99M
Net Calls
+$3.23M
Net Calls Change
+$273K

Top Buyers

1
Millennium Management
Millennium Management
New York
+$36.1M
2
LCM
Laurion Capital Management
New York
+$12.9M
3
CWG
C WorldWide Group
Denmark
+$9.29M
4
State Street
State Street
Massachusetts
+$8.53M
5
Alkeon Capital Management
Alkeon Capital Management
New York
+$7.76M

Top Sellers

1
ACA
Avoro Capital Advisors
New York
-$87.6M
2
Two Sigma Investments
Two Sigma Investments
New York
-$19.3M
3
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$15.6M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$11.6M
5
Two Sigma Advisers
Two Sigma Advisers
New York
-$10.5M
Name Holding Trade Value Shares
Change 		Shares
Change %
BlackRock
1
BlackRock
New York
$116M +$4.73M +20,354 +4%
State Street
2
State Street
Massachusetts
$82.7M +$8.53M +36,726 +12%
PAI
3
Palo Alto Investors
California
$81.5M +$2.81M +12,100 +4%
Vanguard Group
4
Vanguard Group
Pennsylvania
$53.9M +$563K +2,423 +1%
FCM
5
Frontier Capital Management
Massachusetts
$48.4M -$8.92M -38,414 -16%
Alkeon Capital Management
6
Alkeon Capital Management
New York
$41.3M +$7.76M +33,434 +23%
Millennium Management
7
Millennium Management
New York
$38.6M +$36.1M +155,329 +1,412%
Adage Capital Partners
8
Adage Capital Partners
Massachusetts
$38.2M -$11.6M -49,862 -23%
DMPV
9
Delphi Management Partners VIII
California
$35M +$35M +150,867 New
Wellington Management Group
10
Wellington Management Group
Massachusetts
$33.7M +$6.76M +29,101 +25%
EA
11
Emerald Advisers
Pennsylvania
$28.2M +$3.4M +14,635 +14%
EMFAT
12
Emerald Mutual Fund Advisers Trust
Pennsylvania
$25.7M +$3.28M +14,115 +15%
RHJA
13
Rice Hall James & Associates
California
$24M +$1.51M +6,485 +7%
T. Rowe Price Associates
14
T. Rowe Price Associates
Maryland
$22.6M +$308K +1,326 +1%
D.E. Shaw & Co
15
D.E. Shaw & Co
New York
$21.4M -$15.6M -67,023 -42%
Goldman Sachs
16
Goldman Sachs
New York
$16.3M +$2.94M +12,672 +22%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$16.1M -$240K -1,033 -1%
Nuveen Asset Management
18
Nuveen Asset Management
Illinois
$15.9M -$382K -1,643 -2%
LCM
19
Laurion Capital Management
New York
$15.2M +$12.9M +55,381 +555%
CS
20
Candriam SCA
Luxembourg
$14.7M +$6.63M +28,548 +82%
HRCM
21
Hood River Capital Management
Florida
$14.4M +$248K +1,066 +2%
Northern Trust
22
Northern Trust
Illinois
$12.1M -$1.1M -4,725 -8%
Morgan Stanley
23
Morgan Stanley
New York
$11.5M +$4.76M +20,489 +71%
FFM
24
Fairmount Funds Management
Pennsylvania
$10.9M – – –
CWG
25
C WorldWide Group
Denmark
$9.29M +$9.29M +40,000 New
1
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