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Karyopharm Therapeutics
KPTI

Overview Fund Activity

143 hedge funds and large institutions have $347M invested in Karyopharm Therapeutics in 2021 Q4 according to their latest regulatory filings, with 29 funds opening new positions, 51 increasing their positions, 46 reducing their positions, and 17 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
143
Holders Change
+9
Holders Change %
+6.72%
% of All Funds
2.21%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
29
Increased
51
Reduced
46
Closed
17
Calls
$4.62M
Puts
$10.3M
Net Calls
-$5.68M
Net Calls Change
+$171K

Top Buyers

1
Millennium Management
Millennium Management
New York
$9.78M
2
FCM
Frontier Capital Management
Massachusetts
$10.8M
3
CSS
Cubist Systematic Strategies
Connecticut
$3.62M
4
CWG
C WorldWide Group
Denmark
$9.65M
5
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
$4.78M

Top Sellers

1
State Street
State Street
Massachusetts
$35.5M
2
Morgan Stanley
Morgan Stanley
New York
$6.85M
3
Two Sigma Advisers
Two Sigma Advisers
New York
$2.75M
4
RCMNY
Rubric Capital Management (New York)
New York
$17.9M
5
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
$92.7K
Name Holding Trade Value Shares
Change 		Shares
Change %
BlackRock
1
BlackRock
New York
$57.3M +$822K +8,526 +1%
State Street
2
State Street
Massachusetts
$35.5M -$16.1M -167,088 -31%
PAI
3
Palo Alto Investors
California
$35.2M +$562K +5,827 +2%
Vanguard Group
4
Vanguard Group
Pennsylvania
$21.6M -$1.83M -18,927 -8%
RCMNY
5
Rubric Capital Management (New York)
New York
$17.9M -$3.82M -39,555 -18%
Alkeon Capital Management
6
Alkeon Capital Management
New York
$12.6M – – –
FCM
7
Frontier Capital Management
Massachusetts
$10.8M +$3.75M +38,865 +53%
LOAMS
8
Lombard Odier Asset Management (Switzerland)
Switzerland
$10.7M +$902K +9,349 +9%
Millennium Management
9
Millennium Management
New York
$9.78M +$9.78M +101,348 New
CWG
10
C WorldWide Group
Denmark
$9.65M +$1.93M +20,000 +25%
Geode Capital Management
11
Geode Capital Management
Massachusetts
$9.28M +$229K +2,372 +3%
RHJA
12
Rice Hall James & Associates
California
$8.21M -$805K -8,348 -9%
Morgan Stanley
13
Morgan Stanley
New York
$6.85M -$5.32M -55,155 -44%
Nuveen Asset Management
14
Nuveen Asset Management
Illinois
$6.72M +$370K +4,353 +6%
Goldman Sachs
15
Goldman Sachs
New York
$6.62M +$280K +2,900 +4%
Two Sigma Investments
16
Two Sigma Investments
New York
$6.36M -$692K -7,177 -10%
CS
17
Candriam SCA
Luxembourg
$5.64M +$1.03M +10,666 +22%
Northern Trust
18
Northern Trust
Illinois
$4.99M +$54.6K +566 +1%
JPMorgan Chase & Co
19
JPMorgan Chase & Co
New York
$4.78M +$1.79M +18,565 +60%
Susquehanna International Group
20
Susquehanna International Group
Pennsylvania
$3.88M +$402K +4,162 +12%
CSS
21
Cubist Systematic Strategies
Connecticut
$3.62M +$3.01M +31,169 +487%
Two Sigma Advisers
22
Two Sigma Advisers
New York
$2.75M -$4.21M -43,626 -60%
HWAM
23
Hennion & Walsh Asset Management
New Jersey
$2.53M -$88.6K -919 -3%
Macquarie Group
24
Macquarie Group
Australia
$2.46M – – –
Rafferty Asset Management
25
Rafferty Asset Management
New York
$2.45M +$61.6K +639 +3%
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