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Karyopharm Therapeutics

81 hedge funds and large institutions have $701M invested in Karyopharm Therapeutics in 2014 Q4 according to their latest regulatory filings, with 19 funds opening new positions, 29 increasing their positions, 19 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

138% more first-time investments, than exits

New positions opened: 19 | Existing positions closed: 8

53% more repeat investments, than reductions

Existing positions increased: 29 | Existing positions reduced: 19

19% more capital invested

Capital invested by funds: $587M → $701M (+$114M)

14% more funds holding

Funds holding: 7181 (+10)

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

19% less call options, than puts

Call options by funds: $1.34M | Put options by funds: $1.65M

Holders
81
Holders Change
+10
Holders Change %
+14.08%
% of All Funds
2.16%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.05%
New
19
Increased
29
Reduced
19
Closed
8
Calls
$1.34M
Puts
$1.65M
Net Calls
-$306K
Net Calls Change
-$90K
Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$184M +$32M +56,403 +21%
Franklin Resources
2
Franklin Resources
California
$174M +$8.81M +15,517 +5%
FCMI
3
Foresite Capital Management I
California
$37.4M -$2.95M -5,190 -7%
PHS
4
PFM Health Sciences
California
$31.8M -$10.4M -18,368 -24%
BFA
5
BlackRock Fund Advisors
California
$28.6M +$16.8M +29,533 +137%
State Street
6
State Street
Massachusetts
$25.2M +$4.07M +7,163 +19%
BA
7
BlackRock Advisors
Delaware
$22.7M -$4.43M -7,792 -16%
SAM
8
Sectoral Asset Management
Quebec, Canada
$19.8M +$1.57M +2,772 +9%
AllianceBernstein
9
AllianceBernstein
Tennessee
$15.7M -$2.02M -3,564 -11%
Vanguard Group
10
Vanguard Group
Pennsylvania
$15.6M +$1.31M +2,300 +9%
CAM
11
Cormorant Asset Management
Massachusetts
$14.4M
CS
12
Candriam SCA
Luxembourg
$11.2M +$11.3M +19,867 New
BIT
13
BlackRock Institutional Trust
California
$8.2M +$2.96M +5,204 +55%
Wellington Management Group
14
Wellington Management Group
Massachusetts
$8.09M -$4.23M -7,452 -34%
BG
15
BlackRock Group
United Kingdom
$7.86M -$792K -1,394 -9%
GC
16
Guggenheim Capital
Illinois
$7.08M +$3.94M +6,941 +122%
UBS Group
17
UBS Group
Switzerland
$6.95M +$7.03M +12,383 New
TG
18
TCW Group
California
$6.29M +$1.17M +2,063 +23%
Northern Trust
19
Northern Trust
Illinois
$5.56M -$101K -178 -2%
TCM
20
Tekla Capital Management
Massachusetts
$5.16M +$1.36M +2,386 +35%
NLVP
21
New Leaf Venture Partners
New York
$4.74M +$4.8M +8,446 New
UBS AM
22
UBS AM
Illinois
$4.2M +$3.95M +6,947 +1,286%
Deutsche Bank
23
Deutsche Bank
Germany
$4.02M +$1.04M +1,833 +34%
PC
24
PointState Capital
New York
$3.74M
BBA
25
Baker Bros. Advisors
New York
$3.52M

KPTI Hedge Fund Activity: Q4 2014 in Review

81 of the 3,751 institutional investors tracked by Wall St. Rank reported a position in Karyopharm Therapeutics (KPTI) for Q4 2014, worth a combined $701M — up 19% from $587M a quarter earlier.

Buyers outnumbered sellers: 19 funds opened new KPTI positions and 8 closed out — a net gain of 11 holders — while 29 added to existing stakes and 19 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $32M. The largest seller was PFM Health Sciences, cutting an estimated $10.4M.

  • 81 institutional investors held Karyopharm Therapeutics (KPTI) as of Q4 2014, up from 71 in Q3 2014.
  • Funds reported $701M of Karyopharm Therapeutics stock for Q4 2014, up 19% quarter-over-quarter.
  • 19 funds opened new Karyopharm Therapeutics positions in Q4 2014 and 8 closed out, a net change of +11 holders.
  • The largest Karyopharm Therapeutics buyer in Q4 2014 was Fidelity Investments, an estimated $32M added.
  • The largest Karyopharm Therapeutics seller in Q4 2014 was PFM Health Sciences, an estimated $10.4M sold.

Based on aggregated 13F filings for Q4 2014.