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Karyopharm Therapeutics
KPTI

Overview Fund Activity

50 hedge funds and large institutions have $19M invested in Karyopharm Therapeutics in 2025 Q2 according to their latest regulatory filings, with 11 funds opening new positions, 13 increasing their positions, 7 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
50
Holders Change
+3
Holders Change %
+6.38%
% of All Funds
0.67%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
11
Increased
13
Reduced
7
Closed
8
Calls
$1.61M
Puts
$127K
Net Calls
+$1.48M
Net Calls Change
+$995K

Top Buyers

1
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$2.54M
2
Group One Trading
Group One Trading
Illinois
+$422K
3
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$369K
4
SAM
Silverback Asset Management
North Carolina
+$302K
5
UBS Group
UBS Group
Switzerland
+$294K

Top Sellers

1
PAI
Palo Alto Investors
California
-$587K
2
Millennium Management
Millennium Management
New York
-$101K
3
SC
Shay Capital
New York
-$95.1K
4
UOC
UBS O'Connor
Illinois
-$88.4K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
-$43.2K
Name Holding Trade Value Shares
Change 		Shares
Change %
T. Rowe Price Investment Management
1
T. Rowe Price Investment Management
Maryland
$3.14M +$2.54M +589,120 +422%
Vanguard Group
2
Vanguard Group
Pennsylvania
$2.23M +$34.4K +7,975 +2%
Adage Capital Partners
3
Adage Capital Partners
Massachusetts
$1.82M – – –
EP
4
Eversept Partners
New York
$1.11M – – –
JPMorgan Chase & Co
5
JPMorgan Chase & Co
New York
$1.11M +$369K +85,653 +50%
BlackRock
6
BlackRock
New York
$1.02M -$26.3K -6,101 -3%
Citadel Advisors
7
Citadel Advisors
Florida
$891K -$552 -128 -0.1%
PAI
8
Palo Alto Investors
California
$810K -$587K -136,121 -42%
Bank of America
9
Bank of America
North Carolina
$726K +$154K +35,626 +27%
UBS Group
10
UBS Group
Switzerland
$698K +$294K +68,288 +73%
CCM
11
Catalio Capital Management
New York
$629K -$41.4K -9,609 -6%
APM
12
Avidity Partners Management
Texas
$580K – – –
Marshall Wace
13
Marshall Wace
United Kingdom
$554K – – –
Goldman Sachs
14
Goldman Sachs
New York
$472K +$103K +23,994 +28%
CWG
15
C WorldWide Group
Denmark
$431K – – –
Group One Trading
16
Group One Trading
Illinois
$422K +$422K +97,900 New
Geode Capital Management
17
Geode Capital Management
Massachusetts
$396K -$33.6K -7,799 -8%
SAM
18
Silverback Asset Management
North Carolina
$302K +$302K +70,000 New
Renaissance Technologies
19
Renaissance Technologies
New York
$284K +$19.8K +4,600 +8%
BCM
20
Bridgeway Capital Management
Texas
$163K +$163K +37,836 New
State Street
21
State Street
Massachusetts
$144K +$16.4K +3,800 +13%
Millennium Management
22
Millennium Management
New York
$137K -$101K -23,520 -42%
BNP Paribas Financial Markets
23
BNP Paribas Financial Markets
France
$128K +$2.91K +676 +2%
BC
24
Birchview Capital
Vermont
$121K – – –
IC
25
Ikarian Capital
Texas
$117K – – –
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