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Karyopharm Therapeutics
KPTI

Overview Fund Activity

139 hedge funds and large institutions have $499M invested in Karyopharm Therapeutics in 2022 Q1 according to their latest regulatory filings, with 26 funds opening new positions, 42 increasing their positions, 46 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
139
Holders Change
-4
Holders Change %
-2.8%
% of All Funds
2.2%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.02%
New
26
Increased
42
Reduced
46
Closed
28
Calls
$12M
Puts
$4.09M
Net Calls
+$7.88M
Net Calls Change
+$13.6M

Top Buyers

1
State Street
State Street
Massachusetts
$80.8M
2
CC
Commodore Capital
New York
$26.2M
3
ITP
Iron Triangle Partners
Connecticut
$14.7M
4
Morgan Stanley
Morgan Stanley
New York
$20.7M
5
Bank of America
Bank of America
North Carolina
$8.23M

Top Sellers

1
Alkeon Capital Management
Alkeon Capital Management
New York
$0
2
BlackRock
BlackRock
New York
$58.4M
3
LOAMS
Lombard Odier Asset Management (Switzerland)
Switzerland
$5.72M
4
FCM
Frontier Capital Management
Massachusetts
$9.43M
5
CSS
Cubist Systematic Strategies
Connecticut
$1.19M
Name Holding Trade Value Shares
Change 		Shares
Change %
State Street
1
State Street
Massachusetts
$80.8M +$40.2M +363,534 +99%
BlackRock
2
BlackRock
New York
$58.4M -$7.3M -66,039 -11%
PAI
3
Palo Alto Investors
California
$41.4M +$1.11M +10,072 +3%
Vanguard Group
4
Vanguard Group
Pennsylvania
$29.2M +$4.44M +40,127 +18%
RCMNY
5
Rubric Capital Management (New York)
New York
$26.6M +$6.08M +55,000 +30%
CC
6
Commodore Capital
New York
$26.2M +$26.2M +237,403 New
Morgan Stanley
7
Morgan Stanley
New York
$20.7M +$12.9M +116,463 +164%
ITP
8
Iron Triangle Partners
Connecticut
$14.7M +$14.7M +133,333 New
Nuveen Asset Management
9
Nuveen Asset Management
Illinois
$11.9M +$4.16M +42,316 +54%
CWG
10
C WorldWide Group
Denmark
$11.1M – – –
RHJA
11
Rice Hall James & Associates
California
$9.91M +$503K +4,553 +5%
Geode Capital Management
12
Geode Capital Management
Massachusetts
$9.86M -$773K -6,989 -7%
CS
13
Candriam SCA
Luxembourg
$9.84M +$3.37M +30,491 +52%
FCM
14
Frontier Capital Management
Massachusetts
$9.43M -$2.99M -27,074 -24%
Millennium Management
15
Millennium Management
New York
$9.23M -$1.97M -17,823 -18%
Two Sigma Investments
16
Two Sigma Investments
New York
$8.24M +$950K +8,593 +13%
Bank of America
17
Bank of America
North Carolina
$8.23M +$6.35M +57,424 +338%
Goldman Sachs
18
Goldman Sachs
New York
$6.63M -$958K -8,665 -13%
Citadel Advisors
19
Citadel Advisors
Florida
$6.3M +$4.61M +41,709 +273%
Rafferty Asset Management
20
Rafferty Asset Management
New York
$5.96M +$3.16M +28,558 +113%
LOAMS
21
Lombard Odier Asset Management (Switzerland)
Switzerland
$5.72M -$6.5M -58,799 -53%
Two Sigma Advisers
22
Two Sigma Advisers
New York
$5.71M +$2.56M +23,180 +81%
Northern Trust
23
Northern Trust
Illinois
$5.63M -$82.6K -747 -1%
JPMorgan Chase & Co
24
JPMorgan Chase & Co
New York
$5.3M -$183K -1,651 -3%
Voloridge Investment Management
25
Voloridge Investment Management
Florida
$4.99M +$3.53M +31,963 +243%
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