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Karyopharm Therapeutics

146 hedge funds and large institutions have $1.13B invested in Karyopharm Therapeutics in 2019 Q4 according to their latest regulatory filings, with 52 funds opening new positions, 41 increasing their positions, 39 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed

400% more funds holding in top 10

Funds holding in top 10: 15 (+4)

373% more first-time investments, than exits

New positions opened: 52 | Existing positions closed: 11

101% more capital invested

Capital invested by funds: $563M → $1.13B (+$567M)

38% more funds holding

Funds holding: 106146 (+40)

5% more call options, than puts

Call options by funds: $16.5M | Put options by funds: $15.6M

5% more repeat investments, than reductions

Existing positions increased: 41 | Existing positions reduced: 39

0.04% less ownership

Funds ownership: 6.3%6.26% (-0.04%)

Holders
146
Holders Change
+40
Holders Change %
+37.74%
% of All Funds
2.88%
Holding in Top 10
5
Holding in Top 10 Change
+4
Holding in Top 10 Change %
+400%
% of All Funds
0.1%
New
52
Increased
41
Reduced
39
Closed
11
Calls
$16.5M
Puts
$15.6M
Net Calls
+$838K
Net Calls Change
+$955K
Name Holding Trade Value Shares
Change
Change in
Stake
CCM
1
Consonance Capital Management
New York
$117M +$4.19M +19,334 +5%
ACA
2
Avoro Capital Advisors
New York
$113M -$2.17M -10,000 -2%
BlackRock
3
BlackRock
New York
$91.4M +$1.03M +4,759 +2%
PAI
4
Palo Alto Investors
California
$88.1M -$3.57M -16,477 -5%
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$72.6M +$30.2M +139,134 +123%
State Street
6
State Street
Massachusetts
$61.9M +$1.15M +5,323 +3%
Vanguard Group
7
Vanguard Group
Pennsylvania
$53M +$309K +1,422 +0.8%
D.E. Shaw & Co
8
D.E. Shaw & Co
New York
$45.3M +$14.2M +65,633 +71%
DMPV
9
Delphi Management Partners VIII
California
$43.4M +$32.7M +150,867 New
Citadel Advisors
10
Citadel Advisors
Florida
$26.7M -$1.99M -9,173 -9%
Wellington Management Group
11
Wellington Management Group
Massachusetts
$26M -$63.6M -293,270 -76%
Dimensional Fund Advisors
12
Dimensional Fund Advisors
Texas
$22.6M -$449K -2,068 -3%
FCM
13
Frontier Capital Management
Massachusetts
$19.5M -$10.9M -50,448 -43%
CS
14
Candriam SCA
Luxembourg
$16.2M -$3.28M -15,126 -21%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$15.9M +$565K +2,606 +5%
Federated Hermes
16
Federated Hermes
Pennsylvania
$15.7M +$11.8M +54,484 New
Two Sigma Investments
17
Two Sigma Investments
New York
$14.4M +$10.6M +48,774 +3,368%
Northern Trust
18
Northern Trust
Illinois
$14.1M -$60.3K -278 -0.6%
HRCM
19
Hood River Capital Management
Florida
$13.7M +$945K +4,357 +10%
Fidelity Investments
20
Fidelity Investments
Massachusetts
$12.1M -$2.06M -9,500 -18%
O
21
OrbiMed
New York
$11.9M -$6.42M -29,600 -42%
ACP
22
Acuta Capital Partners
California
$11.3M +$5.1M +23,500 +148%
Goldman Sachs
23
Goldman Sachs
New York
$10.7M -$290K -1,338 -3%
Two Sigma Advisers
24
Two Sigma Advisers
New York
$10M +$4.64M +21,380 +158%
EA
25
Emerald Advisers
Pennsylvania
$9.61M -$14.4M -66,355 -67%

KPTI Hedge Fund Activity: Q4 2019 in Review

146 of the 5,076 institutional investors tracked by Wall St. Rank reported a position in Karyopharm Therapeutics (KPTI) for Q4 2019, worth a combined $1.13B — up 101% from $563M a quarter earlier.

Buyers outnumbered sellers: 52 funds opened new KPTI positions and 11 closed out — a net gain of 41 holders — while 41 added to existing stakes and 39 trimmed.

The largest buyer was Adage Capital Partners, adding an estimated $30.2M. The largest seller was Wellington Management Group, cutting an estimated $63.6M.

  • 146 institutional investors held Karyopharm Therapeutics (KPTI) as of Q4 2019, up from 106 in Q3 2019.
  • Funds reported $1.13B of Karyopharm Therapeutics stock for Q4 2019, up 101% quarter-over-quarter.
  • 52 funds opened new Karyopharm Therapeutics positions in Q4 2019 and 11 closed out, a net change of +41 holders.
  • The largest Karyopharm Therapeutics buyer in Q4 2019 was Adage Capital Partners, an estimated $30.2M added.
  • The largest Karyopharm Therapeutics seller in Q4 2019 was Wellington Management Group, an estimated $63.6M sold.

Based on aggregated 13F filings for Q4 2019.