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Karyopharm Therapeutics
KPTI

Overview Fund Activity

146 hedge funds and large institutions have $1.13B invested in Karyopharm Therapeutics in 2019 Q4 according to their latest regulatory filings, with 52 funds opening new positions, 41 increasing their positions, 39 reducing their positions, and 11 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
146
Holders Change
+40
Holders Change %
+37.74%
% of All Funds
2.88%
Holding in Top 10
5
Holding in Top 10 Change
+4
Holding in Top 10 Change %
+400%
% of All Funds
0.1%
New
52
Increased
41
Reduced
39
Closed
11
Calls
$16.5M
Puts
$15.6M
Net Calls
+$838K
Net Calls Change
+$955K

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$40M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$18.9M
3
Federated Hermes
Federated Hermes
Pennsylvania
+$15.7M
4
Two Sigma Investments
Two Sigma Investments
New York
+$14M
5
ACP
Acuta Capital Partners
California
+$6.76M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$84.3M
2
Millennium Management
Millennium Management
New York
-$24.4M
3
EA
Emerald Advisers
Pennsylvania
-$19.1M
4
EMFAT
Emerald Mutual Fund Advisers Trust
Pennsylvania
-$18.1M
5
ECP
Elk Creek Partners
Colorado
-$15.5M
Name Holding Trade Value Shares
Change 		Shares
Change %
CCM
1
Consonance Capital Management
New York
$117M +$5.56M +19,334 +5%
ACA
2
Avoro Capital Advisors
New York
$113M -$2.88M -10,000 -2%
BlackRock
3
BlackRock
New York
$91.4M +$1.37M +4,759 +2%
PAI
4
Palo Alto Investors
California
$88.1M -$4.74M -16,477 -5%
Adage Capital Partners
5
Adage Capital Partners
Massachusetts
$72.6M +$40M +139,134 +123%
State Street
6
State Street
Massachusetts
$61.9M +$1.53M +5,323 +3%
Vanguard Group
7
Vanguard Group
Pennsylvania
$53M +$409K +1,422 +0.8%
D.E. Shaw & Co
8
D.E. Shaw & Co
New York
$45.3M +$18.9M +65,633 +71%
DMPV
9
Delphi Management Partners VIII
California
$43.4M +$43.4M +150,867 New
Citadel Advisors
10
Citadel Advisors
Florida
$26.7M -$2.64M -9,173 -9%
Wellington Management Group
11
Wellington Management Group
Massachusetts
$26M -$84.3M -293,270 -76%
Dimensional Fund Advisors
12
Dimensional Fund Advisors
Texas
$22.6M -$595K -2,068 -3%
FCM
13
Frontier Capital Management
Massachusetts
$19.5M -$14.5M -50,448 -43%
CS
14
Candriam SCA
Luxembourg
$16.2M -$4.35M -15,126 -21%
Geode Capital Management
15
Geode Capital Management
Massachusetts
$15.9M +$749K +2,606 +5%
Federated Hermes
16
Federated Hermes
Pennsylvania
$15.7M +$15.7M +54,484 New
Two Sigma Investments
17
Two Sigma Investments
New York
$14.4M +$14M +48,774 +3,368%
Northern Trust
18
Northern Trust
Illinois
$14.1M -$79.9K -278 -0.6%
HRCM
19
Hood River Capital Management
Florida
$13.7M +$1.25M +4,357 +10%
Fidelity Investments
20
Fidelity Investments
Massachusetts
$12.1M -$2.73M -9,500 -18%
O
21
OrbiMed
New York
$11.9M -$8.51M -29,600 -42%
ACP
22
Acuta Capital Partners
California
$11.3M +$6.76M +23,500 +148%
Goldman Sachs
23
Goldman Sachs
New York
$10.7M -$385K -1,338 -3%
Two Sigma Advisers
24
Two Sigma Advisers
New York
$10M +$6.15M +21,380 +158%
EA
25
Emerald Advisers
Pennsylvania
$9.61M -$19.1M -66,355 -67%
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