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Karyopharm Therapeutics

106 hedge funds and large institutions have $563M invested in Karyopharm Therapeutics in 2019 Q3 according to their latest regulatory filings, with 24 funds opening new positions, 40 increasing their positions, 25 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed

84% more capital invested

Capital invested by funds: $306M → $563M (+$256M)

60% more repeat investments, than reductions

Existing positions increased: 40 | Existing positions reduced: 25

14% more first-time investments, than exits

New positions opened: 24 | Existing positions closed: 21

3% more funds holding

Funds holding: 103106 (+3)

0.69% more ownership

Funds ownership: 5.6%6.3% (+0.69%)

3% less call options, than puts

Call options by funds: $3.67M | Put options by funds: $3.78M

Holders
106
Holders Change
+3
Holders Change %
+2.91%
% of All Funds
2.32%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.02%
New
24
Increased
40
Reduced
25
Closed
21
Calls
$3.67M
Puts
$3.78M
Net Calls
-$117K
Net Calls Change
-$3.89M
Name Holding Trade Value Shares
Change
Change in
Stake
ACA
1
Avoro Capital Advisors
New York
$58.2M +$54.7M +403,333 New
CCM
2
Consonance Capital Management
New York
$56.2M +$309K +2,280 +0.6%
Wellington Management Group
3
Wellington Management Group
Massachusetts
$55.4M -$24.2M -178,716 -32%
PAI
4
Palo Alto Investors
California
$46.6M -$3.8M -28,008 -8%
BlackRock
5
BlackRock
New York
$45.2M +$1.55M +11,402 +4%
State Street
6
State Street
Massachusetts
$30.3M +$18.3M +135,253 +181%
Vanguard Group
7
Vanguard Group
Pennsylvania
$26.4M -$2.16M -15,953 -8%
FCM
8
Frontier Capital Management
Massachusetts
$17.1M +$9.88M +72,867 +160%
Adage Capital Partners
9
Adage Capital Partners
Massachusetts
$16.4M +$15.4M +113,333 New
Citadel Advisors
10
Citadel Advisors
Florida
$14.7M +$5.87M +43,310 +74%
EA
11
Emerald Advisers
Pennsylvania
$14.4M +$184K +1,356 +1%
EMFAT
12
Emerald Mutual Fund Advisers Trust
Pennsylvania
$13.8M +$520K +3,836 +4%
D.E. Shaw & Co
13
D.E. Shaw & Co
New York
$13.3M +$5.2M +38,371 +71%
Millennium Management
14
Millennium Management
New York
$12.4M +$11M +80,869 +1,669%
ECP
15
Elk Creek Partners
Colorado
$12.2M +$11.5M +84,715 New
Dimensional Fund Advisors
16
Dimensional Fund Advisors
Texas
$11.6M +$953K +7,027 +10%
CS
17
Candriam SCA
Luxembourg
$10.3M -$7.9M -58,303 -45%
O
18
OrbiMed
New York
$10.3M -$18.8M -138,838 -66%
Geode Capital Management
19
Geode Capital Management
Massachusetts
$7.58M +$146K +1,078 +2%
Fidelity Investments
20
Fidelity Investments
Massachusetts
$7.45M -$2.47M -18,253 -26%
Northern Trust
21
Northern Trust
Illinois
$7.14M +$1.15M +8,475 +21%
HRCM
22
Hood River Capital Management
Florida
$6.26M +$5.88M +43,403 New
Goldman Sachs
23
Goldman Sachs
New York
$5.54M +$3.71M +27,357 +248%
AI
24
Atom Investors
Texas
$3.9M -$133K -984 -4%
N
25
Nuveen
North Carolina
$3.83M +$116K +854 +3%

KPTI Hedge Fund Activity: Q3 2019 in Review

106 of the 4,561 institutional investors tracked by Wall St. Rank reported a position in Karyopharm Therapeutics (KPTI) for Q3 2019, worth a combined $563M — up 84% from $306M a quarter earlier.

Buyers outnumbered sellers: 24 funds opened new KPTI positions and 21 closed out — a net gain of 3 holders — while 40 added to existing stakes and 25 trimmed.

The largest buyer was Avoro Capital Advisors, opening a new position worth an estimated $54.7M. The largest seller was Wellington Management Group, cutting an estimated $24.2M.

  • 106 institutional investors held Karyopharm Therapeutics (KPTI) as of Q3 2019, up from 103 in Q2 2019.
  • Funds reported $563M of Karyopharm Therapeutics stock for Q3 2019, up 84% quarter-over-quarter.
  • 24 funds opened new Karyopharm Therapeutics positions in Q3 2019 and 21 closed out, a net change of +3 holders.
  • The largest Karyopharm Therapeutics buyer in Q3 2019 was Avoro Capital Advisors, an estimated $54.7M added.
  • The largest Karyopharm Therapeutics seller in Q3 2019 was Wellington Management Group, an estimated $24.2M sold.

Based on aggregated 13F filings for Q3 2019.