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Karyopharm Therapeutics
KPTI

Overview Fund Activity

47 hedge funds and large institutions have $13.7M invested in Karyopharm Therapeutics in 2025 Q1 according to their latest regulatory filings, with 2 funds opening new positions, 8 increasing their positions, 30 reducing their positions, and 42 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
47
Holders Change
-40
Holders Change %
-45.98%
% of All Funds
0.64%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
2
Increased
8
Reduced
30
Closed
42
Calls
$581K
Puts
$95K
Net Calls
+$486K
Net Calls Change
+$337K

Top Buyers

1
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$570K
2
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$523K
3
Bank of America
Bank of America
North Carolina
+$457K
4
EP
Eversept Partners
New York
+$441K
5
UBS Group
UBS Group
Switzerland
+$314K

Top Sellers

1
GCP
GSA Capital Partners
United Kingdom
-$1.08M
2
Deutsche Bank
Deutsche Bank
Germany
-$863K
3
Morgan Stanley
Morgan Stanley
New York
-$837K
4
KCM
Kennedy Capital Management
Missouri
-$808K
5
SCM
Silverarc Capital Management
Massachusetts
-$403K
Name Holding Trade Value Shares
Change 		Shares
Change %
Vanguard Group
1
Vanguard Group
Pennsylvania
$1.91M -$19 -5 -0%
Adage Capital Partners
2
Adage Capital Partners
Massachusetts
$1.58M -$4 -1 -0%
PAI
3
Palo Alto Investors
California
$1.21M -$11.6K -3,101 -0.9%
EP
4
Eversept Partners
New York
$962K +$441K +117,904 +85%
BlackRock
5
BlackRock
New York
$908K -$31.9K -8,516 -3%
Citadel Advisors
6
Citadel Advisors
Florida
$774K -$7 -2 -0%
JPMorgan Chase & Co
7
JPMorgan Chase & Co
New York
$639K +$570K +152,376 +828%
CCM
8
Catalio Capital Management
New York
$582K -$11 -3 -0%
T. Rowe Price Investment Management
9
T. Rowe Price Investment Management
Maryland
$523K +$523K +139,646 New
APM
10
Avidity Partners Management
Texas
$503K -$4 -1 -0%
Bank of America
11
Bank of America
North Carolina
$497K +$457K +122,127 +1,133%
Marshall Wace
12
Marshall Wace
United Kingdom
$480K -$118K -31,643 -20%
CWG
13
C WorldWide Group
Denmark
$374K – – –
Geode Capital Management
14
Geode Capital Management
Massachusetts
$373K +$25.5K +6,819 +7%
UBS Group
15
UBS Group
Switzerland
$350K +$314K +83,893 +863%
Goldman Sachs
16
Goldman Sachs
New York
$319K -$13.6K -3,641 -4%
Renaissance Technologies
17
Renaissance Technologies
New York
$229K -$70.9K -18,959 -24%
Millennium Management
18
Millennium Management
New York
$207K -$80.8K -21,594 -28%
SAM
19
Silverback Asset Management
North Carolina
$187K – – –
ACM
20
Altium Capital Management
New York
$185K – – –
State Street
21
State Street
Massachusetts
$110K -$22 -6 -0%
BNP Paribas Financial Markets
22
BNP Paribas Financial Markets
France
$108K -$219K -58,632 -67%
BC
23
Birchview Capital
Vermont
$105K -$15 -4 -0%
IC
24
Ikarian Capital
Texas
$102K -$11 -3 -0%
SC
25
Shay Capital
New York
$95.1K +$52.1K +13,940 +121%
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