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Karyopharm Therapeutics

115 hedge funds and large institutions have $482M invested in Karyopharm Therapeutics in 2018 Q4 according to their latest regulatory filings, with 15 funds opening new positions, 49 increasing their positions, 34 reducing their positions, and 17 closing their positions.

New
Increased
Maintained
Reduced
Closed

44% more repeat investments, than reductions

Existing positions increased: 49 | Existing positions reduced: 34

0.88% more ownership

Funds ownership: 4.77%5.65% (+0.88%)

0% more funds holding in top 10

Funds holding in top 10: 11 (0)

3% less funds holding

Funds holding: 119115 (-4)

12% less first-time investments, than exits

New positions opened: 15 | Existing positions closed: 17

35% less capital invested

Capital invested by funds: $738M → $482M (-$256M)

38% less call options, than puts

Call options by funds: $553K | Put options by funds: $894K

Holders
115
Holders Change
-4
Holders Change %
-3.36%
% of All Funds
2.56%
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.02%
New
15
Increased
49
Reduced
34
Closed
17
Calls
$553K
Puts
$894K
Net Calls
-$341K
Net Calls Change
+$2.08M
Name Holding Trade Value Shares
Change
Change in
Stake
Wellington Management Group
1
Wellington Management Group
Massachusetts
$77M -$1.66M -9,833 -2%
CCM
2
Consonance Capital Management
New York
$45.1M -$191K -1,133 -0.4%
PAI
3
Palo Alto Investors
California
$43.9M +$248K +1,469 +0.5%
BlackRock
4
BlackRock
New York
$39.9M -$29.4K -174 -0.1%
RCI
5
Ridgeback Capital Investments
Florida
$37M +$44.4M +263,013 New
State Street
6
State Street
Massachusetts
$23.6M +$6.55M +38,845 +30%
Fidelity Investments
7
Fidelity Investments
Massachusetts
$17.6M +$7.17M +42,490 +51%
Franklin Resources
8
Franklin Resources
California
$16.9M -$453K -2,688 -2%
CS
9
Candriam SCA
Luxembourg
$16.8M +$7.95M +47,136 +65%
Vanguard Group
10
Vanguard Group
Pennsylvania
$16.2M -$7.69M -45,600 -28%
Point72 Asset Management
11
Point72 Asset Management
Connecticut
$14.4M +$7.77M +46,081 +81%
EA
12
Emerald Advisers
Pennsylvania
$13.6M +$8.57M +50,827 +110%
EMFAT
13
Emerald Mutual Fund Advisers Trust
Pennsylvania
$12.9M +$8.17M +48,408 +112%
Dimensional Fund Advisors
14
Dimensional Fund Advisors
Texas
$6.31M +$4.65M +27,560 +159%
Two Sigma Investments
15
Two Sigma Investments
New York
$5.73M +$2.39M +14,147 +53%
Northern Trust
16
Northern Trust
Illinois
$5.7M -$150K -889 -2%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$5.23M +$296K +1,757 +5%
Deutsche Bank
18
Deutsche Bank
Germany
$4.49M +$1.49M +8,850 +38%
DM
19
Deerfield Management
New York
$4.45M
Millennium Management
20
Millennium Management
New York
$4.19M -$4.37M -25,889 -46%
PCA
21
Private Capital Advisors
Connecticut
$4.17M -$326K -1,933 -6%
Renaissance Technologies
22
Renaissance Technologies
New York
$3.99M +$4M +23,704 +503%
TCIM
23
TIAA CREF Investment Management
New York
$3.58M -$1.56M -9,239 -27%
Macquarie Group
24
Macquarie Group
Australia
$3.56M +$473K +2,806 +12%
TA
25
Teachers Advisors
New York
$3.19M +$39.1K +232 +1%

KPTI Hedge Fund Activity: Q4 2018 in Review

115 of the 4,489 institutional investors tracked by Wall St. Rank reported a position in Karyopharm Therapeutics (KPTI) for Q4 2018, worth a combined $482M — down 35% from $738M a quarter earlier.

Sellers outnumbered buyers: 17 funds closed out of KPTI and 15 opened new positions — a net loss of 2 holders — while 34 trimmed existing stakes and 49 added.

The largest buyer was Emerald Advisers, adding an estimated $8.57M. The largest seller was Vanguard Group, cutting an estimated $7.69M.

  • 115 institutional investors held Karyopharm Therapeutics (KPTI) as of Q4 2018, down from 119 in Q3 2018.
  • Funds reported $482M of Karyopharm Therapeutics stock for Q4 2018, down 35% quarter-over-quarter.
  • 15 funds opened new Karyopharm Therapeutics positions in Q4 2018 and 17 closed out, a net change of -2 holders.
  • The largest Karyopharm Therapeutics buyer in Q4 2018 was Emerald Advisers, an estimated $8.57M added.
  • The largest Karyopharm Therapeutics seller in Q4 2018 was Vanguard Group, an estimated $7.69M sold.

Based on aggregated 13F filings for Q4 2018.