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Karyopharm Therapeutics
KPTI

Overview Fund Activity

129 hedge funds and large institutions have $340M invested in Karyopharm Therapeutics in 2023 Q1 according to their latest regulatory filings, with 18 funds opening new positions, 52 increasing their positions, 30 reducing their positions, and 43 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
129
Holders Change
-25
Holders Change %
-16.23%
% of All Funds
2.06%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.02%
New
18
Increased
52
Reduced
30
Closed
43
Calls
$1.03M
Puts
$515K
Net Calls
+$519K
Net Calls Change
-$184K

Top Buyers

1
Vanguard Group
Vanguard Group
Pennsylvania
$29.2M
2
State Street
State Street
Massachusetts
$39.6M
3
Barclays
Barclays
United Kingdom
$11.1M
4
OM
Opaleye Management
Massachusetts
$10.9M
5
SCM
Silverarc Capital Management
Massachusetts
$6M

Top Sellers

1
RCMNY
Rubric Capital Management (New York)
New York
$17.3M
2
AC
Armistice Capital
New York
$0
3
Point72 Asset Management
Point72 Asset Management
Connecticut
$0
4
CC
Commodore Capital
New York
$0
5
ITP
Iron Triangle Partners
Connecticut
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
State Street
1
State Street
Massachusetts
$39.6M +$7.35M +125,930 +23%
APM
2
Avidity Partners Management
Texas
$37.5M – – –
BlackRock
3
BlackRock
New York
$35.3M +$2.19M +37,597 +7%
Vanguard Group
4
Vanguard Group
Pennsylvania
$29.2M +$8.97M +153,756 +44%
PAI
5
Palo Alto Investors
California
$22.1M +$78.6K +1,347 +0.4%
RCMNY
6
Rubric Capital Management (New York)
New York
$17.3M -$15M -256,905 -46%
Citadel Advisors
7
Citadel Advisors
Florida
$14M -$431K -7,380 -3%
Barclays
8
Barclays
United Kingdom
$11.1M +$7.01M +120,045 +172%
OM
9
Opaleye Management
Massachusetts
$10.9M +$6.24M +106,931 +133%
Bank of America
10
Bank of America
North Carolina
$8.39M +$2.52M +43,108 +43%
Marshall Wace
11
Marshall Wace
United Kingdom
$7.72M -$876K -15,021 -10%
Nuveen Asset Management
12
Nuveen Asset Management
Illinois
$6.92M +$719K +12,322 +12%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$6.89M +$1.54M +26,307 +29%
Deutsche Bank
14
Deutsche Bank
Germany
$6.4M +$4.09M +70,040 +177%
SCM
15
Silverarc Capital Management
Massachusetts
$6M +$6M +102,762 New
CWG
16
C WorldWide Group
Denmark
$5.84M – – –
Goldman Sachs
17
Goldman Sachs
New York
$5.71M +$1.6M +27,501 +39%
CS
18
Candriam SCA
Luxembourg
$5.5M – – –
Jacobs Levy Equity Management
19
Jacobs Levy Equity Management
New Jersey
$4.18M -$4.57M -78,288 -52%
Rafferty Asset Management
20
Rafferty Asset Management
New York
$3.55M +$843K +14,443 +31%
Northern Trust
21
Northern Trust
Illinois
$3.21M +$307K +5,267 +11%
Renaissance Technologies
22
Renaissance Technologies
New York
$2.86M +$2.13M +36,427 +289%
Citigroup
23
Citigroup
New York
$2.84M +$861K +14,762 +44%
Morgan Stanley
24
Morgan Stanley
New York
$2.83M -$2.19M -37,516 -44%
UOC
25
UBS O'Connor
Illinois
$2.31M +$2.31M +39,587 New
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