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Karyopharm Therapeutics
KPTI

Overview Fund Activity

49 hedge funds and large institutions have $19M invested in Karyopharm Therapeutics in 2025 Q2 according to their latest regulatory filings, with 11 funds opening new positions, 13 increasing their positions, 7 reducing their positions, and 7 closing their positions.

Holders
49
Holders Change
+2
Holders Change %
+4.26%
% of All Funds
0.66%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
11
Increased
13
Reduced
7
Closed
7
Calls
$1.54M
Puts
$127K
Net Calls
+$1.41M
Net Calls Change
+$924K

Top Buyers

1
T. Rowe Price Investment Management
1
T. Rowe Price Investment Management
Maryland
$3.14M
2
Group One Trading
2
Group One Trading
Illinois
$422K
3
JPMorgan Chase & Co
3
JPMorgan Chase & Co
New York
$1.11M
4
SAM
4
Silverback Asset Management
North Carolina
$302K
5
UBS Group
5
UBS Group
Switzerland
$698K

Top Sellers

1
PAI
1
Palo Alto Investors
California
$810K
2
ACM
2
Altium Capital Management
New York
$0
3
Millennium Management
3
Millennium Management
New York
$137K
4
SC
4
Shay Capital
New York
$0
5
UOC
5
UBS O'Connor
Illinois
$0
Name Market Value Shares Shares
Change 		Shares
Change %
T. Rowe Price Investment Management
1
T. Rowe Price Investment Management
Maryland
$3.14M 728,766 +589,120 +422%
Vanguard Group
2
Vanguard Group
Pennsylvania
$2.23M 518,269 +7,975 +2%
Adage Capital Partners
3
Adage Capital Partners
Massachusetts
$1.82M 421,322 – –
EP
4
Eversept Partners
New York
$1.11M 257,154 – –
JPMorgan Chase & Co
5
JPMorgan Chase & Co
New York
$1.11M 256,443 +85,653 +50%
BlackRock
6
BlackRock
New York
$1.02M 236,641 -6,101 -3%
Citadel Advisors
7
Citadel Advisors
Florida
$891K 206,781 -128 -0.1%
PAI
8
Palo Alto Investors
California
$810K 187,911 -136,121 -42%
Bank of America
9
Bank of America
North Carolina
$726K 168,534 +35,626 +27%
UBS Group
10
UBS Group
Switzerland
$698K 161,900 +68,288 +73%
CCM
11
Catalio Capital Management
New York
$629K 146,013 -9,609 -6%
APM
12
Avidity Partners Management
Texas
$580K 134,566 – –
Marshall Wace
13
Marshall Wace
United Kingdom
$554K 128,451 – –
Goldman Sachs
14
Goldman Sachs
New York
$472K 109,404 +23,994 +28%
CWG
15
C WorldWide Group
Denmark
$431K 100,000 – –
Group One Trading
16
Group One Trading
Illinois
$422K 97,900 +97,900 New
Geode Capital Management
17
Geode Capital Management
Massachusetts
$396K 91,841 -7,799 -8%
SAM
18
Silverback Asset Management
North Carolina
$302K 70,000 +70,000 New
Renaissance Technologies
19
Renaissance Technologies
New York
$284K 65,814 +4,600 +8%
BCM
20
Bridgeway Capital Management
Texas
$163K 37,836 +37,836 New
State Street
21
State Street
Massachusetts
$144K 33,295 +3,800 +13%
Millennium Management
22
Millennium Management
New York
$137K 31,847 -23,520 -42%
BNP Paribas Financial Markets
23
BNP Paribas Financial Markets
France
$128K 29,637 +676 +2%
BC
24
Birchview Capital
Vermont
$121K 27,985 – –
IC
25
Ikarian Capital
Texas
$117K 27,257 – –
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