Millennium Management’s Karyopharm Therapeutics KPTI Stock Holding History
Bought
Maintained
Sold
| Quarter | Market Value | Status | Shares |
Change in Stake | Trade Value | Portfolio Weight | Portfolio Position | |
|---|---|---|---|---|---|---|---|---|
|
2026
Q1 | $2.34M | Buy |
+420,571
| New | +$3.21M | ﹤0.01% | 3729 |
|
|
2025
Q3 | – | Sell |
-31,847
| Closed | -$137K | – | 6269 |
|
|
2025
Q2 | $137K | Sell |
31,847
-23,520
| -42% | -$115K | ﹤0.01% | 5468 |
|
|
2025
Q1 | $207K | Sell |
55,367
-21,594
| -28% | -$184K | ﹤0.01% | 5292 |
|
|
2024
Q4 | $781K | Sell |
76,961
-6,723
| -8% | -$81.3K | ﹤0.01% | 4397 |
|
|
2024
Q3 | $1.04M | Sell |
83,684
-55,811
| -40% | -$694K | ﹤0.01% | 4245 |
|
|
2024
Q2 | $1.82M | Buy |
139,495
+60,436
| +76% | +$1M | ﹤0.01% | 3609 |
|
|
2024
Q1 | $1.79M | Sell |
79,059
-23,225
| -23% | -$407K | ﹤0.01% | 3843 |
|
|
2023
Q4 | $1.33M | Buy |
102,284
+27,757
| +37% | +$374K | ﹤0.01% | 3934 |
|
|
2023
Q3 | $1.5M | Sell |
74,527
-2,222
| -3% | -$49.9K | ﹤0.01% | 3840 |
|
|
2023
Q2 | $2.06M | Buy |
76,749
+75,831
| +8,260% | +$3.27M | ﹤0.01% | 3456 |
|
|
2023
Q1 | $54K | Sell |
918
-22,518
| -96% | -$1.11M | ﹤0.01% | 5603 |
|
|
2022
Q4 | $1.2M | Buy |
23,436
+5,924
| +34% | +$411K | ﹤0.01% | 3990 |
|
|
2022
Q3 | $1.43M | Sell |
17,512
-22,847
| -57% | -$1.71M | ﹤0.01% | 4033 |
|
|
2022
Q2 | $2.73M | Sell |
40,359
-43,166
| -52% | -$3.96M | ﹤0.01% | 3390 |
|
|
2022
Q1 | $9.23M | Sell |
83,525
-17,823
| -18% | -$2.22M | ﹤0.01% | 2245 |
|
|
2021
Q4 | $9.78M | Buy |
+101,348
| New | +$10.1M | 0.01% | 2163 |
|
|
2021
Q3 | – | Sell |
-7,668
| Closed | -$1.19M | – | 7039 |
|
|
2021
Q2 | $1.19M | Sell |
7,668
-41,646
| -84% | -$6.04M | ﹤0.01% | 4508 |
|
|
2021
Q1 | $7.78M | Sell |
49,314
-117,013
| -70% | -$24.7M | 0.01% | 2070 |
|
|
2020
Q4 | $38.6M | Buy |
166,327
+155,329
| +1,412% | +$36M | 0.03% | 603 |
|
|
2020
Q3 | $2.41K | Sell |
10,998
-4,848
| -31% | -$1.19M | ﹤0.01% | 2455 |
|
|
2020
Q2 | $4.5M | Buy |
+15,846
| New | +$4.69M | 0.01% | 1870 |
|
|
2020
Q1 | – | Sell |
-900
| Closed | -$248K | – | 4196 |
|
|
2019
Q4 | $259K | Sell |
900
-84,813
| -99% | -$18.4M | ﹤0.01% | 3738 |
|
|
2019
Q3 | $12.4M | Buy |
85,713
+80,869
| +1,669% | +$11M | 0.02% | 1125 |
|
|
2019
Q2 | $435K | Sell |
4,844
-176,470
| -97% | -$14.2M | ﹤0.01% | 3327 |
|
|
2019
Q1 | $15.9M | Buy |
181,314
+151,474
| +508% | +$16.8M | 0.02% | 950 |
|
|
2018
Q4 | $4.19M | Sell |
29,840
-25,889
| -46% | -$4.37M | 0.01% | 1701 |
|
|
2018
Q3 | $14.2M | Sell |
55,729
-13,569
| -20% | -$3.75M | 0.02% | 1052 |
|
|
2018
Q2 | $17.7M | Sell |
69,298
-15,520
| -18% | -$3.84M | 0.02% | 930 |
|
|
2018
Q1 | $17.1M | Buy |
84,818
+55,696
| +191% | +$11.1M | 0.02% | 977 |
|
|
2017
Q4 | $4.19M | Buy |
29,122
+4,394
| +18% | +$706K | 0.01% | 1826 |
|
|
2017
Q3 | $4.07M | Buy |
24,728
+10,118
| +69% | +$1.45M | 0.01% | 1778 |
|
|
2017
Q2 | $1.98M | Sell |
14,610
-2,623
| -15% | -$388K | ﹤0.01% | 2077 |
|
|
2017
Q1 | $3.32M | Sell |
17,233
-30,177
| -64% | -$4.84M | 0.01% | 1705 |
|
|
2016
Q4 | $6.68M | Sell |
47,410
-10,714
| -18% | -$1.45M | 0.01% | 1145 |
|
|
2016
Q3 | $8.48M | Buy |
58,124
+10,517
| +22% | +$1.26M | 0.01% | 1021 |
|
|
2016
Q2 | $4.79M | Sell |
47,607
-39,486
| -45% | -$5.13M | 0.01% | 1286 |
|
|
2016
Q1 | $11.7M | Buy |
87,093
+803
| +0.9% | +$88.6K | 0.03% | 735 |
|
|
2015
Q4 | $17.1M | Buy |
86,290
+17,908
| +26% | +$3.88M | 0.04% | 637 |
|
|
2015
Q3 | $10.8M | Buy |
68,382
+44,085
| +181% | +$11.8M | 0.02% | 893 |
|
|
2015
Q2 | $9.92M | Buy |
24,297
+17,889
| +279% | +$7.73M | 0.02% | 984 |
|
|
2015
Q1 | $2.94M | Buy |
6,408
+3,075
| +92% | +$1.33M | 0.01% | 1719 |
|
|
2014
Q4 | $1.87M | Buy |
+3,333
| New | +$1.89M | ﹤0.01% | 2026 |
|
|
2014
Q3 | – | Sell |
-2,127
| Closed | -$1.49M | – | 3853 |
|
|
2014
Q2 | $1.49M | Buy |
+2,127
| New | +$990K | ﹤0.01% | 1962 |
|
|
2014
Q1 | – | Sell |
-1,430
| Closed | -$492K | – | 3692 |
|
|
2013
Q4 | $492K | Buy |
+1,430
| New | +$395K | ﹤0.01% | 2724 |
|
Other funds holding KPTI
CC
RCM
APM
CCM
VCM
IC
AAA
Millennium Management's KPTI Position: Q1 2026 in Review
Millennium Management opened a new position in Karyopharm Therapeutics (KPTI) in Q1 2026: 420,571 shares worth $2.34M. The stake represents ﹤0.01% of the portfolio and ranks #3729 among its holdings. This is a return to the name: Millennium Management previously reported a position in KPTI as recently as Q2 2025.
Millennium Management first reported a position in KPTI in Q4 2013 and has held it in 44 quarters since. The position peaked at $38.6M in Q4 2020. 77 funds tracked by Wall St. Rank hold KPTI as of Q1 2026.
- Millennium Management held 420,571 shares of Karyopharm Therapeutics worth $2.34M as of Q1 2026.
- Karyopharm Therapeutics was a new Millennium Management position in Q1 2026.
- Karyopharm Therapeutics made up ﹤0.01% of Millennium Management's portfolio in Q1 2026, its #3729 holding.
- Millennium Management first reported a position in Karyopharm Therapeutics in Q4 2013 and has held it in 44 quarters since.
- Millennium Management's Karyopharm Therapeutics position peaked at $38.6M in Q4 2020.
- 77 funds tracked by Wall St. Rank held Karyopharm Therapeutics as of Q1 2026.
Based on Millennium Management's 13F filing for Q1 2026, filed 15 May 2026.