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Karyopharm Therapeutics
KPTI

Overview Fund Activity

50 hedge funds and large institutions have $19M invested in Karyopharm Therapeutics in 2025 Q2 according to their latest regulatory filings, with 11 funds opening new positions, 13 increasing their positions, 7 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
50
Holders Change
+3
Holders Change %
+6.38%
% of All Funds
0.67%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
11
Increased
13
Reduced
7
Closed
8
Calls
$1.61M
Puts
$127K
Net Calls
+$1.48M
Net Calls Change
+$995K

Top Buyers

1
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$2.54M
2
Group One Trading
Group One Trading
Illinois
+$422K
3
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$369K
4
SAM
Silverback Asset Management
North Carolina
+$302K
5
UBS Group
UBS Group
Switzerland
+$294K

Top Sellers

1
PAI
Palo Alto Investors
California
-$587K
2
Millennium Management
Millennium Management
New York
-$101K
3
SC
Shay Capital
New York
-$95.1K
4
UOC
UBS O'Connor
Illinois
-$88.4K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
-$43.2K
Name Holding Trade Value Shares
Change 		Shares
Change %
Morgan Stanley
26
Morgan Stanley
New York
$108K +$63.2K +14,668 +141%
Northern Trust
27
Northern Trust
Illinois
$81.5K – – –
GCP
28
GSA Capital Partners
United Kingdom
$60K +$60K +13,894 New
XT
29
XTX Topco
Cayman Islands
$56.3K +$56.3K +13,056 New
Bank of New York Mellon
30
Bank of New York Mellon
New York
$47.8K – – –
T. Rowe Price Associates
31
T. Rowe Price Associates
Maryland
$47K +$47K +10,886 New
Baird Financial Group
32
Baird Financial Group
Wisconsin
$45.4K +$45.4K +10,532 New
Simplex Trading
33
Simplex Trading
Illinois
$35K +$35K +8,233 New
Royal Bank of Canada
34
Royal Bank of Canada
Ontario, Canada
$32K +$25.7K +5,970 +409%
Citigroup
35
Citigroup
New York
$30.3K -$17 -4 -0.1%
Barclays
36
Barclays
United Kingdom
$23K – – –
TWC
37
TD Waterhouse Canada
Ontario, Canada
$14K – – –
Osaic Holdings
38
Osaic Holdings
Arizona
$3.67K +$3.41K +4,615 +1,334%
TRCT
39
Tower Research Capital (TRC)
New York
$3.66K +$3.66K +850 New
Fidelity Investments
40
Fidelity Investments
Massachusetts
$3.3K +$1.03K +238 +45%
MLA
41
MB, Levis & Associates
Pennsylvania
$431 – – –
Raymond James Financial
42
Raymond James Financial
Florida
$388 +$388 +90 New
HI
43
Harbour Investments
Wisconsin
$366 – – –
FFO
44
Fortitude Family Office
Arizona
$349 +$349 +81 New
SS
45
SBI Securities
Japan
$319 – – –
AWM
46
Activest Wealth Management
Florida
$284 – – –
AF
47
Allworth Financial
California
$138 – – –
BGAI
48
Bruce G. Allen Investments
Colorado
$95 – – –
WBC
49
West Branch Capital
Massachusetts
$13 – – –
CIBC Private Wealth Group
50
CIBC Private Wealth Group
Georgia
$13 – – –
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