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Karyopharm Therapeutics
KPTI

Overview Fund Activity

154 hedge funds and large institutions have $334M invested in Karyopharm Therapeutics in 2022 Q4 according to their latest regulatory filings, with 32 funds opening new positions, 63 increasing their positions, 39 reducing their positions, and 24 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
154
Holders Change
+7
Holders Change %
+4.76%
% of All Funds
2.48%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
32
Increased
63
Reduced
39
Closed
24
Calls
$1.83M
Puts
$1.12M
Net Calls
+$703K
Net Calls Change
-$761K

Top Buyers

1
APM
Avidity Partners Management
Texas
$32.8M
2
RCMNY
Rubric Capital Management (New York)
New York
$28.2M
3
AC
Armistice Capital
New York
$13.1M
4
Marshall Wace
Marshall Wace
United Kingdom
$7.51M
5
Point72 Asset Management
Point72 Asset Management
Connecticut
$6.77M

Top Sellers

1
RHJA
Rice Hall James & Associates
California
$0
2
ACM
Altium Capital Management
New York
$0
3
FCM
Frontier Capital Management
Massachusetts
$0
4
LOAMS
Lombard Odier Asset Management (Switzerland)
Switzerland
$0
5
State Street
State Street
Massachusetts
$28.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
Barclays
26
Barclays
United Kingdom
$3.56M +$2.01M +39,417 +130%
ABG
27
Ally Bridge Group
New York
$3.05M -$2.15M -42,130 -41%
Acadian Asset Management
28
Acadian Asset Management
Massachusetts
$2.87M -$16.4K -322 -0.6%
Adage Capital Partners
29
Adage Capital Partners
Massachusetts
$2.62M +$2.62M +51,381 New
Northern Trust
30
Northern Trust
Illinois
$2.54M -$27.3K -536 -1%
Two Sigma Advisers
31
Two Sigma Advisers
New York
$2.39M -$436K -8,540 -15%
Rafferty Asset Management
32
Rafferty Asset Management
New York
$2.37M +$97.4K +1,910 +4%
AAA
33
Affinity Asset Advisors
New York
$2.25M +$2.25M +44,084 New
Deutsche Bank
34
Deutsche Bank
Germany
$2.02M +$1.73K +34 +0.1%
Qube Research & Technologies (QRT)
35
Qube Research & Technologies (QRT)
United Kingdom
$1.78M +$1.78M +34,919 New
UBS Group
36
UBS Group
Switzerland
$1.78M +$1.4M +27,381 +365%
Citigroup
37
Citigroup
New York
$1.73M -$336K -6,587 -16%
TC
38
Tejara Capital
United Kingdom
$1.71M +$1.71M +33,437 New
CSS
39
Cubist Systematic Strategies
Connecticut
$1.67M +$1.37M +26,776 +455%
Alyeska Investment Group
40
Alyeska Investment Group
Illinois
$1.64M +$1.64M +32,113 New
MIM
41
Monashee Investment Management
Massachusetts
$1.64M +$1.64M +32,113 New
Bank of New York Mellon
42
Bank of New York Mellon
New York
$1.47M +$455K +8,926 +45%
Connor, Clark & Lunn Investment Management (CC&L)
43
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$1.47M +$941K +18,457 +178%
BNP Paribas Financial Markets
44
BNP Paribas Financial Markets
France
$1.44M -$1.15M -22,594 -44%
Macquarie Group
45
Macquarie Group
Australia
$1.29M -$5K -98 -0.4%
Millennium Management
46
Millennium Management
New York
$1.2M +$302K +5,924 +34%
D.E. Shaw & Co
47
D.E. Shaw & Co
New York
$1.05M +$558K +10,944 +114%
BC
48
Birchview Capital
Vermont
$991K +$74.9K +1,467 +8%
Two Sigma Investments
49
Two Sigma Investments
New York
$902K +$126K +2,465 +16%
Swiss National Bank
50
Swiss National Bank
Switzerland
$881K +$305K +5,980 +53%
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