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Karyopharm Therapeutics
KPTI

Overview Fund Activity

139 hedge funds and large institutions have $499M invested in Karyopharm Therapeutics in 2022 Q1 according to their latest regulatory filings, with 26 funds opening new positions, 42 increasing their positions, 46 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
139
Holders Change
-4
Holders Change %
-2.8%
% of All Funds
2.2%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.02%
New
26
Increased
42
Reduced
46
Closed
28
Calls
$12M
Puts
$4.09M
Net Calls
+$7.88M
Net Calls Change
+$13.6M

Top Buyers

1
State Street
State Street
Massachusetts
+$40.2M
2
CC
Commodore Capital
New York
+$26.2M
3
ITP
Iron Triangle Partners
Connecticut
+$14.7M
4
Morgan Stanley
Morgan Stanley
New York
+$12.9M
5
Bank of America
Bank of America
North Carolina
+$6.35M

Top Sellers

1
Alkeon Capital Management
Alkeon Capital Management
New York
-$12.6M
2
BlackRock
BlackRock
New York
-$7.3M
3
LOAMS
Lombard Odier Asset Management (Switzerland)
Switzerland
-$6.5M
4
FCM
Frontier Capital Management
Massachusetts
-$2.99M
5
CSS
Cubist Systematic Strategies
Connecticut
-$2.96M
Name Holding Trade Value Shares
Change 		Shares
Change %
PP
76
PDT Partners
New York
$227K +$227K +2,052 New
Manulife (Manufacturers Life Insurance)
77
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$217K -$64.8K -586 -23%
TI
78
Trexquant Investment
Connecticut
$215K -$1.42M -12,784 -87%
WMSA
79
Weiss Multi-Strategy Advisers
New York
$205K -$14.7K -133 -7%
AQR Capital Management
80
AQR Capital Management
Connecticut
$205K +$205K +1,855 New
Walleye Trading
81
Walleye Trading
New York
$195K +$128K +1,158 +191%
T. Rowe Price Associates
82
T. Rowe Price Associates
Maryland
$194K +$43.4K +392 +29%
Lazard Asset Management
83
Lazard Asset Management
New York
$182K -$50.1K -454 -22%
Dimensional Fund Advisors
84
Dimensional Fund Advisors
Texas
$174K – – –
CL
85
CSS LLC
Illinois
$173K +$173K +1,562 New
DCM
86
Dupont Capital Management
Delaware
$167K -$218K -1,978 -57%
BAM
87
Blueshift Asset Management
New Jersey
$164K +$164K +1,482 New
MC
88
Moors & Cabot
Massachusetts
$159K – – –
ProShare Advisors
89
ProShare Advisors
Maryland
$158K -$37.6K -338 -19%
ECM
90
ExodusPoint Capital Management
New York
$144K -$661K -5,961 -82%
Los Angeles Capital Management
91
Los Angeles Capital Management
California
$138K +$138K +1,245 New
ASRS
92
Arizona State Retirement System
Arizona
$135K +$661 +6 +0.5%
Baird Financial Group
93
Baird Financial Group
Wisconsin
$126K -$20.5K -185 -14%
Royal Bank of Canada
94
Royal Bank of Canada
Ontario, Canada
$123K -$108K -968 -47%
Man Group
95
Man Group
United Kingdom
$113K +$113K +1,018 New
SOW
96
State of Wyoming
Wyoming
$111K +$5.07K +46 +5%
XT
97
XTX Topco
Cayman Islands
$106K +$10.1K +92 +11%
Teacher Retirement System of Texas
98
Teacher Retirement System of Texas
Texas
$103K +$6.41K +58 +7%
Creative Planning
99
Creative Planning
Kansas
$97K – – –
Principal Financial Group
100
Principal Financial Group
Iowa
$97K +$6.99K +63 +8%
2 3
4
5 6