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Karyopharm Therapeutics
KPTI

Overview Fund Activity

47 hedge funds and large institutions have $13.7M invested in Karyopharm Therapeutics in 2025 Q1 according to their latest regulatory filings, with 2 funds opening new positions, 8 increasing their positions, 30 reducing their positions, and 42 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
47
Holders Change
-40
Holders Change %
-45.98%
% of All Funds
0.64%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
2
Increased
8
Reduced
30
Closed
42
Calls
$581K
Puts
$95K
Net Calls
+$486K
Net Calls Change
+$337K

Top Buyers

1
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$570K
2
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$523K
3
Bank of America
Bank of America
North Carolina
+$457K
4
EP
Eversept Partners
New York
+$441K
5
UBS Group
UBS Group
Switzerland
+$314K

Top Sellers

1
GCP
GSA Capital Partners
United Kingdom
-$1.08M
2
Deutsche Bank
Deutsche Bank
Germany
-$863K
3
Morgan Stanley
Morgan Stanley
New York
-$837K
4
KCM
Kennedy Capital Management
Missouri
-$808K
5
SCM
Silverarc Capital Management
Massachusetts
-$403K
Name Holding Trade Value Shares
Change 		Shares
Change %
KCM
51
Kennedy Capital Management
Missouri
– -$808K -79,686 Closed
SCM
52
Silverarc Capital Management
Massachusetts
– -$403K -39,733 Closed
Macquarie Group
53
Macquarie Group
Australia
– -$338K -33,333 Closed
Acadian Asset Management
54
Acadian Asset Management
Massachusetts
– -$230K -22,856 Closed
CSS
55
Cubist Systematic Strategies
Connecticut
– -$222K -21,920 Closed
AI
56
Atom Investors
Texas
– -$176K -17,322 Closed
BCM
57
Bridgeway Capital Management
Texas
– -$162K -15,967 Closed
D.E. Shaw & Co
58
D.E. Shaw & Co
New York
– -$155K -15,312 Closed
ETC
59
Exchange Traded Concepts
Oklahoma
– -$148K -14,586 Closed
Two Sigma Investments
60
Two Sigma Investments
New York
– -$93.2K -9,186 Closed
WP
61
Woodline Partners
California
– -$90.7K -8,941 Closed
OCM
62
Opti Capital Management
New York
– -$84.5K -8,333 Closed
BFM
63
Boothbay Fund Management
New York
– -$61.3K -6,042 Closed
PAS
64
Point72 Asia (Singapore)
Singapore
– -$57.3K -5,647 Closed
Two Sigma Advisers
65
Two Sigma Advisers
New York
– -$51.8K -5,107 Closed
Prudential Financial
66
Prudential Financial
New Jersey
– -$50.5K -4,973 Closed
T. Rowe Price Associates
67
T. Rowe Price Associates
Maryland
– -$44K -4,287 Closed
Charles Schwab
68
Charles Schwab
California
– -$34.6K -3,412 Closed
Focus Partners Wealth
69
Focus Partners Wealth
Massachusetts
– -$31K -3,055 Closed
Baird Financial Group
70
Baird Financial Group
Wisconsin
– -$30.3K -2,987 Closed
HSBC Holdings
71
HSBC Holdings
United Kingdom
– -$26.5K -2,687 Closed
VCIM
72
Velan Capital Investment Management
Georgia
– -$27.1K -2,667 Closed
FIM
73
Freedom Investment Management
Connecticut
– -$26.2K -2,579 Closed
KIG
74
Kennedy Investment Group
New Jersey
– -$23.7K -2,333 Closed
RS
75
R Squared
Hong Kong
– -$20.1K -1,978 Closed
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