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Karyopharm Therapeutics
KPTI

Overview Fund Activity

47 hedge funds and large institutions have $13.7M invested in Karyopharm Therapeutics in 2025 Q1 according to their latest regulatory filings, with 2 funds opening new positions, 8 increasing their positions, 30 reducing their positions, and 42 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
47
Holders Change
-40
Holders Change %
-45.98%
% of All Funds
0.64%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
2
Increased
8
Reduced
30
Closed
42
Calls
$581K
Puts
$95K
Net Calls
+$486K
Net Calls Change
+$337K

Top Buyers

1
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
+$570K
2
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$523K
3
Bank of America
Bank of America
North Carolina
+$457K
4
EP
Eversept Partners
New York
+$441K
5
UBS Group
UBS Group
Switzerland
+$314K

Top Sellers

1
GCP
GSA Capital Partners
United Kingdom
-$1.08M
2
Deutsche Bank
Deutsche Bank
Germany
-$863K
3
Morgan Stanley
Morgan Stanley
New York
-$837K
4
KCM
Kennedy Capital Management
Missouri
-$808K
5
SCM
Silverarc Capital Management
Massachusetts
-$403K
Name Holding Trade Value Shares
Change 		Shares
Change %
UOC
26
UBS O'Connor
Illinois
$88.4K -$282K -75,275 -76%
Northern Trust
27
Northern Trust
Illinois
$70.7K -$19 -5 -0%
Susquehanna International Group
28
Susquehanna International Group
Pennsylvania
$43.2K -$122K -32,728 -74%
Jane Street
29
Jane Street
New York
$42.7K -$144K -38,467 -77%
Bank of New York Mellon
30
Bank of New York Mellon
New York
$41.5K -$7 -2 -0%
Morgan Stanley
31
Morgan Stanley
New York
$39K -$837K -223,790 -96%
Citigroup
32
Citigroup
New York
$26.3K -$4 -1 -0%
Barclays
33
Barclays
United Kingdom
$19K -$3.71K -1,041 -16%
TWC
34
TD Waterhouse Canada
Ontario, Canada
$11.3K – – –
Royal Bank of Canada
35
Royal Bank of Canada
Ontario, Canada
$5K +$3.52K +1,026 +237%
Fidelity Investments
36
Fidelity Investments
Massachusetts
$1.97K -$101K -26,970 -98%
Osaic Holdings
37
Osaic Holdings
Arizona
$1.29K -$49 -13 -4%
CCM
38
Coldstream Capital Management
Washington
$1.24K +$1.24K +331 New
QC
39
Quent Capital
New York
$864 -$7 -2 -0.9%
VWA
40
VSM Wealth Advisory
Maryland
$497 – – –
MLA
41
MB, Levis & Associates
Pennsylvania
$374 – – –
HI
42
Harbour Investments
Wisconsin
$318 -$7 -2 -2%
SS
43
SBI Securities
Japan
$277 +$97 +26 +54%
AWM
44
Activest Wealth Management
Florida
$247 -$4 -1 -1%
AF
45
Allworth Financial
California
$192 -$6 -1 -3%
BGAI
46
Bruce G. Allen Investments
Colorado
$82 -$4 -1 -4%
WBC
47
West Branch Capital
Massachusetts
$12 – – –
CIBC Private Wealth Group
48
CIBC Private Wealth Group
Georgia
$12 – – –
GCP
49
GSA Capital Partners
United Kingdom
– -$1.08M -106,562 Closed
Deutsche Bank
50
Deutsche Bank
Germany
– -$863K -84,585 Closed
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