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Karyopharm Therapeutics
KPTI

Overview Fund Activity

87 hedge funds and large institutions have $41.2M invested in Karyopharm Therapeutics in 2024 Q4 according to their latest regulatory filings, with 14 funds opening new positions, 21 increasing their positions, 23 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
87
Holders Change
-4
Holders Change %
-4.4%
% of All Funds
1.16%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
14
Increased
21
Reduced
23
Closed
18
Calls
$196K
Puts
$47K
Net Calls
+$149K
Net Calls Change
-$712K

Top Buyers

1
Morgan Stanley
Morgan Stanley
New York
$2.38M
2
Adage Capital Partners
Adage Capital Partners
Massachusetts
$4.27M
3
Jane Street
Jane Street
New York
$506K
4
Susquehanna International Group
Susquehanna International Group
Pennsylvania
$449K
5
Marshall Wace
Marshall Wace
United Kingdom
$1.63M

Top Sellers

1
EP
Eversept Partners
New York
$1.41M
2
AA
AlphaCentric Advisors
Puerto Rico
$0
3
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
$187K
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
$155K
5
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
$889K
Name Holding Trade Value Shares
Change 		Shares
Change %
State Street
26
State Street
Massachusetts
$299K +$22.3K +2,200 +8%
BC
27
Birchview Capital
Vermont
$284K -$33.8K -3,333 -11%
Fidelity Investments
28
Fidelity Investments
Massachusetts
$279K +$28.9K +2,849 +12%
IC
29
Ikarian Capital
Texas
$277K -$304 -30 -0.1%
Acadian Asset Management
30
Acadian Asset Management
Massachusetts
$230K -$17.2K -1,711 -7%
CSS
31
Cubist Systematic Strategies
Connecticut
$222K -$113K -11,162 -34%
Northern Trust
32
Northern Trust
Illinois
$192K +$36.6K +3,604 +24%
JPMorgan Chase & Co
33
JPMorgan Chase & Co
New York
$187K -$750K -73,968 -80%
AI
34
Atom Investors
Texas
$176K – – –
BCM
35
Bridgeway Capital Management
Texas
$162K – – –
D.E. Shaw & Co
36
D.E. Shaw & Co
New York
$155K -$553K -54,514 -78%
ETC
37
Exchange Traded Concepts
Oklahoma
$148K – – –
SC
38
Shay Capital
New York
$116K +$116K +11,477 New
Bank of New York Mellon
39
Bank of New York Mellon
New York
$112K – – –
Bank of America
40
Bank of America
North Carolina
$109K -$45.4K -4,482 -29%
UBS Group
41
UBS Group
Switzerland
$98.6K +$7.65K +754 +8%
Two Sigma Investments
42
Two Sigma Investments
New York
$93.2K +$35.1K +3,457 +60%
WP
43
Woodline Partners
California
$90.7K – – –
OCM
44
Opti Capital Management
New York
$84.5K +$84.5K +8,333 New
Citigroup
45
Citigroup
New York
$71.5K -$10 -1 -0%
Barclays
46
Barclays
United Kingdom
$65K -$102 -10 -0.2%
BFM
47
Boothbay Fund Management
New York
$61.3K -$314 -31 -0.5%
PAS
48
Point72 Asia (Singapore)
Singapore
$57.3K +$1.53K +151 +3%
Two Sigma Advisers
49
Two Sigma Advisers
New York
$51.8K +$30.7K +3,027 +146%
Prudential Financial
50
Prudential Financial
New Jersey
$50.5K – – –
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