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Karyopharm Therapeutics

118 hedge funds and large institutions have $103M invested in Karyopharm Therapeutics in 2023 Q3 according to their latest regulatory filings, with 16 funds opening new positions, 40 increasing their positions, 29 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

331% more call options, than puts

Call options by funds: $785K | Put options by funds: $182K

38% more repeat investments, than reductions

Existing positions increased: 40 | Existing positions reduced: 29

0.27% less ownership

Funds ownership: 4.77%4.5% (-0.27%)

14% less funds holding

Funds holding: 137118 (-19)

29% less capital invested

Capital invested by funds: $145M → $103M (-$42.2M)

54% less first-time investments, than exits

New positions opened: 16 | Existing positions closed: 35

Holders
118
Holders Change
-19
Holders Change %
-13.87%
% of All Funds
1.87%
Holding in Top 10
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
16
Increased
40
Reduced
29
Closed
35
Calls
$785K
Puts
$182K
Net Calls
+$603K
Net Calls Change
+$232K
Name Holding Trade Value Shares
Change
Change in
Stake
Renaissance Technologies
26
Renaissance Technologies
New York
$979K +$94.3K +4,200 +9%
Bank of New York Mellon
27
Bank of New York Mellon
New York
$876K -$10.4K -464 -1%
D.E. Shaw & Co
28
D.E. Shaw & Co
New York
$835K +$37.5K +1,673 +4%
BC
29
Birchview Capital
Vermont
$766K +$420K +18,700 +96%
GCP
30
GSA Capital Partners
United Kingdom
$762K +$850K +37,887 New
SCM
31
Silverarc Capital Management
Massachusetts
$753K +$64.3K +2,865 +8%
AQR Capital Management
32
AQR Capital Management
Connecticut
$672K +$505K +22,517 +206%
PL
33
Parkwood LLC
Ohio
$661K
N
34
Nuveen
North Carolina
$606K -$16.7K -742 -2%
WVP
35
Worth Venture Partners
New Jersey
$598K
IC
36
Ikarian Capital
Texas
$536K
Macquarie Group
37
Macquarie Group
Australia
$509K
Ameriprise
38
Ameriprise
Minnesota
$478K -$4.74K -211 -0.9%
Bank of America
39
Bank of America
North Carolina
$473K +$24.2K +1,079 +5%
XT
40
XTX Topco
Cayman Islands
$415K -$110K -4,919 -19%
BCM
41
Bridgeway Capital Management
Texas
$388K +$433K +19,300 New
Fidelity Investments
42
Fidelity Investments
Massachusetts
$357K +$539 +24 +0.1%
Charles Schwab
43
Charles Schwab
California
$347K -$68K -3,029 -15%
AllianceBernstein
44
AllianceBernstein
Tennessee
$258K -$62.3K -2,775 -18%
DCM
45
DAFNA Capital Management
California
$258K
AI
46
Atom Investors
Texas
$256K +$9.29K +414 +3%
RhumbLine Advisers
47
RhumbLine Advisers
Massachusetts
$185K +$5.34K +238 +3%
Susquehanna International Group
48
Susquehanna International Group
Pennsylvania
$185K +$73K +3,253 +55%
WP
49
Woodline Partners
California
$180K +$201K +8,941 New
JGC
50
J. Goldman & Co
New York
$161K -$628K -27,983 -78%

KPTI Hedge Fund Activity: Q3 2023 in Review

118 of the 6,301 institutional investors tracked by Wall St. Rank reported a position in Karyopharm Therapeutics (KPTI) for Q3 2023, worth a combined $103M — down 29% from $145M a quarter earlier.

Sellers outnumbered buyers: 35 funds closed out of KPTI and 16 opened new positions — a net loss of 19 holders — while 29 trimmed existing stakes and 40 added.

The largest buyer was Jacobs Levy Equity Management, adding an estimated $2.51M. The largest seller was Opaleye Management, exiting entirely with an estimated $3.2M sold.

  • 118 institutional investors held Karyopharm Therapeutics (KPTI) as of Q3 2023, down from 137 in Q2 2023.
  • Funds reported $103M of Karyopharm Therapeutics stock for Q3 2023, down 29% quarter-over-quarter.
  • 16 funds opened new Karyopharm Therapeutics positions in Q3 2023 and 35 closed out, a net change of -19 holders.
  • The largest Karyopharm Therapeutics buyer in Q3 2023 was Jacobs Levy Equity Management, an estimated $2.51M added.
  • The largest Karyopharm Therapeutics seller in Q3 2023 was Opaleye Management, an estimated $3.2M sold.

Based on aggregated 13F filings for Q3 2023.