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Karyopharm Therapeutics
KPTI

139 hedge funds and large institutions have $499M invested in Karyopharm Therapeutics in 2022 Q1 according to their latest regulatory filings, with 26 funds opening new positions, 42 increasing their positions, 46 reducing their positions, and 28 closing their positions.

New
Increased
Maintained
Reduced
Closed

193% more call options, than puts

Call options by funds: $12M | Put options by funds: $4.09M

44% more capital invested

Capital invested by funds: $347M → $499M (+$152M)

0.97% more ownership

Funds ownership: 4.78% → 5.75% (+0.97%)

7% less first-time investments, than exits

New positions opened: 26 | Existing positions closed: 28

9% less repeat investments, than reductions

Existing positions increased: 42 | Existing positions reduced: 46

3% less funds holding

Funds holding: 143 → 139 (-4)

Holders
139
Holders Change
-4
Holders Change %
-2.8%
% of All Funds
2.19%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
% of All Funds
0.02%
New
26
Increased
42
Reduced
46
Closed
28
Calls
$12M
Puts
$4.09M
Net Calls
+$7.88M
Net Calls Change
+$13.6M

Top Buyers

Rank Fund Capital Flow
1
State Street
State Street
Massachusetts
+$45.3M
2
CC
Commodore Capital
New York
+$29.6M
3
ITP
Iron Triangle Partners
Connecticut
+$16.6M
4
Morgan Stanley
Morgan Stanley
New York
+$14.5M
5
Bank of America
Bank of America
North Carolina
+$7.16M

Top Sellers

Rank Fund Capital Flow
1
Alkeon Capital Management
Alkeon Capital Management
New York
-$12.6M
2
BlackRock
BlackRock
New York
-$8.23M
3
LOAMS
Lombard Odier Asset Management (Switzerland)
Switzerland
-$7.33M
4
FCM
Frontier Capital Management
Massachusetts
-$3.37M
5
CSS
Cubist Systematic Strategies
Connecticut
-$3.34M
Name Holding Trade Value Shares
Change 		Change in
Stake
Jacobs Levy Equity Management
26
Jacobs Levy Equity Management
New Jersey
$4.89M +$5.51M +44,234 New
ACM
27
Altium Capital Management
New York
$4.75M +$5.36M +43,000 New
Deutsche Bank
28
Deutsche Bank
Germany
$4.42M +$4.58M +36,764 +1,150%
UBS Group
29
UBS Group
Switzerland
$3.82M +$2.09M +16,764 +94%
Acadian Asset Management
30
Acadian Asset Management
Massachusetts
$3.67M +$4.15M +33,261 New
Jane Street
31
Jane Street
New York
$3.07M +$1.74M +13,980 +101%
HWAM
32
Hennion & Walsh Asset Management
New Jersey
$2.84M -$65.3K -524 -2%
Balyasny Asset Management
33
Balyasny Asset Management
Illinois
$2.52M +$2.85M +22,832 New
Bank of New York Mellon
34
Bank of New York Mellon
New York
$2.19M -$5.36K -43 -0.2%
Susquehanna International Group
35
Susquehanna International Group
Pennsylvania
$2.07M -$2.67M -21,446 -53%
BC
36
Birchview Capital
Vermont
$1.99M +$194K +1,555 +9%
PPA
37
Parametric Portfolio Associates
Washington
$1.89M -$176K -1,415 -8%
Renaissance Technologies
38
Renaissance Technologies
New York
$1.58M +$1.07M +8,613 +150%
Victory Capital Management
39
Victory Capital Management
Texas
$1.46M +$1.64M +13,171 New
Wellington Management Group
40
Wellington Management Group
Massachusetts
$1.45M -$43.4K -348 -3%
Charles Schwab
41
Charles Schwab
California
$1.43M +$50.2K +403 +3%
Allianz Asset Management
42
Allianz Asset Management
Germany
$1.21M -$192K -1,541 -12%
CSS
43
Cubist Systematic Strategies
Connecticut
$1.19M -$3.34M -26,803 -71%
Swiss National Bank
44
Swiss National Bank
Switzerland
$1.19M +$94K +754 +8%
CS
45
Credit Suisse
Switzerland
$1.02M +$632K +5,068 +122%
Citigroup
46
Citigroup
New York
$942K -$1.46M -11,754 -58%
AllianceBernstein
47
AllianceBernstein
Tennessee
$855K +$1.62K +13 +0.2%
Fidelity Investments
48
Fidelity Investments
Massachusetts
$840K +$947K +7,598 New
State of Wisconsin Investment Board
49
State of Wisconsin Investment Board
Wisconsin
$706K – – –
California State Teachers Retirement System (CalSTRS)
50
California State Teachers Retirement System (CalSTRS)
California
$661K -$57.8K -464 -7%
1
2
3 4 5

KPTI Hedge Fund Activity: Q1 2022 in Review

139 of the 6,340 institutional investors tracked by Wall St. Rank reported a position in Karyopharm Therapeutics (KPTI) for Q1 2022, worth a combined $499M — up 44% from $347M a quarter earlier.

Sellers outnumbered buyers: 28 funds closed out of KPTI and 26 opened new positions — a net loss of 2 holders — while 46 trimmed existing stakes and 42 added.

The largest buyer was State Street, adding an estimated $45.3M. The largest seller was Alkeon Capital Management, exiting entirely with an estimated $12.6M sold.

  • 139 institutional investors held Karyopharm Therapeutics (KPTI) as of Q1 2022, down from 143 in Q4 2021.
  • Funds reported $499M of Karyopharm Therapeutics stock for Q1 2022, up 44% quarter-over-quarter.
  • 26 funds opened new Karyopharm Therapeutics positions in Q1 2022 and 28 closed out, a net change of -2 holders.
  • The largest Karyopharm Therapeutics buyer in Q1 2022 was State Street, an estimated $45.3M added.
  • The largest Karyopharm Therapeutics seller in Q1 2022 was Alkeon Capital Management, an estimated $12.6M sold.

Based on aggregated 13F filings for Q1 2022.