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Karyopharm Therapeutics
KPTI

Overview Fund Activity

49 hedge funds and large institutions have $19M invested in Karyopharm Therapeutics in 2025 Q2 according to their latest regulatory filings, with 11 funds opening new positions, 13 increasing their positions, 7 reducing their positions, and 7 closing their positions.

Holders
49
Holders Change
+2
Holders Change %
+4.26%
% of All Funds
0.66%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
11
Increased
13
Reduced
7
Closed
7
Calls
$1.54M
Puts
$127K
Net Calls
+$1.41M
Net Calls Change
+$924K

Top Buyers

1
T. Rowe Price Investment Management
1
T. Rowe Price Investment Management
Maryland
$3.14M
2
Group One Trading
2
Group One Trading
Illinois
$422K
3
JPMorgan Chase & Co
3
JPMorgan Chase & Co
New York
$1.11M
4
SAM
4
Silverback Asset Management
North Carolina
$302K
5
UBS Group
5
UBS Group
Switzerland
$698K

Top Sellers

1
PAI
1
Palo Alto Investors
California
$810K
2
Millennium Management
2
Millennium Management
New York
$137K
3
SC
3
Shay Capital
New York
$0
4
UOC
4
UBS O'Connor
Illinois
$0
5
Jane Street
5
Jane Street
New York
$0
Name Market Value Shares Shares
Change 		Shares
Change %
Morgan Stanley
26
Morgan Stanley
New York
$108K 25,091 +14,668 +141%
Northern Trust
27
Northern Trust
Illinois
$81.5K 18,910 – –
GCP
28
GSA Capital Partners
United Kingdom
$60K 13,894 +13,894 New
XT
29
XTX Topco
Cayman Islands
$56.3K 13,056 +13,056 New
Bank of New York Mellon
30
Bank of New York Mellon
New York
$47.8K 11,086 – –
T. Rowe Price Associates
31
T. Rowe Price Associates
Maryland
$47K 10,886 +10,886 New
Baird Financial Group
32
Baird Financial Group
Wisconsin
$45.4K 10,532 +10,532 New
Simplex Trading
33
Simplex Trading
Illinois
$35K 8,233 +8,233 New
Royal Bank of Canada
34
Royal Bank of Canada
Ontario, Canada
$32K 7,429 +5,970 +409%
Citigroup
35
Citigroup
New York
$30.3K 7,040 -4 -0.1%
Barclays
36
Barclays
United Kingdom
$23K 5,333 – –
TWC
37
TD Waterhouse Canada
Ontario, Canada
$14K 3,203 – –
Osaic Holdings
38
Osaic Holdings
Arizona
$3.67K 4,961 +4,615 +1,334%
TRCT
39
Tower Research Capital (TRC)
New York
$3.66K 850 +850 New
Fidelity Investments
40
Fidelity Investments
Massachusetts
$3.3K 765 +238 +45%
MLA
41
MB, Levis & Associates
Pennsylvania
$431 100 – –
Raymond James Financial
42
Raymond James Financial
Florida
$388 90 +90 New
HI
43
Harbour Investments
Wisconsin
$366 85 – –
FFO
44
Fortitude Family Office
Arizona
$349 81 +81 New
SS
45
SBI Securities
Japan
$319 74 – –
AWM
46
Activest Wealth Management
Florida
$284 66 – –
AF
47
Allworth Financial
California
$138 32 – –
BGAI
48
Bruce G. Allen Investments
Colorado
$95 22 – –
CIBC Private Wealth Group
49
CIBC Private Wealth Group
Georgia
$13 3 – –
WBC
50
West Branch Capital
Massachusetts
$13 3 – –
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2
3