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Spyre Therapeutics
SYRE

Overview Fund Activity

129 hedge funds and large institutions have $1B invested in Spyre Therapeutics in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 52 increasing their positions, 35 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
129
Holders Change
-2
Holders Change %
-1.53%
% of All Funds
1.75%
Holding in Top 10
2
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-50%
% of All Funds
0.03%
New
20
Increased
52
Reduced
35
Closed
21
Calls
$827K
Puts
$1.01M
Net Calls
-$182K
Net Calls Change
-$264K

Top Buyers

1
Capital International Investors
Capital International Investors
California
+$38.6M
2
TCM
Tang Capital Management
California
+$33.1M
3
PBA
Paradigm Biocapital Advisors
New York
+$9.68M
4
Bank of America
Bank of America
North Carolina
+$6.78M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$3.83M

Top Sellers

1
Citadel Advisors
Citadel Advisors
Florida
-$15.3M
2
LGM
Logos Global Management
California
-$11.6M
3
BCM
Boxer Capital Management
California
-$10.9M
4
Goldman Sachs
Goldman Sachs
New York
-$8.88M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$7.45M
Name Holding Trade Value Shares
Change 		Shares
Change %
US Bancorp
126
US Bancorp
Minnesota
$145 +$145 +9 New
SS
127
SBI Securities
Japan
$81 – – –
Amundi
128
Amundi
France
$70 -$378 -27 -84%
LGM
129
Logos Global Management
California
– -$11.6M -500,000 Closed
BCM
130
Boxer Capital Management
California
– -$10.9M -466,680 Closed
IC
131
Ikarian Capital
Texas
– -$6.57M -282,159 Closed
Millennium Management
132
Millennium Management
New York
– -$3.91M -167,804 Closed
BFM
133
Boothbay Fund Management
New York
– -$1.99M -85,618 Closed
Ensign Peak Advisors
134
Ensign Peak Advisors
Utah
– -$1.92M -82,475 Closed
First Trust Advisors
135
First Trust Advisors
Illinois
– -$548K -23,550 Closed
CCM
136
Cinctive Capital Management
New York
– -$456K -19,567 Closed
BHCM
137
Brevan Howard Capital Management
Jersey
– -$393K -16,899 Closed
Teacher Retirement System of Texas
138
Teacher Retirement System of Texas
Texas
– -$242K -10,383 Closed
Two Sigma Investments
139
Two Sigma Investments
New York
– -$224K -9,638 Closed
CG
140
Carlyle Group
District of Columbia
– -$224K -9,620 Closed
State Board of Administration of Florida Retirement System
141
State Board of Administration of Florida Retirement System
Florida
– -$210K -9,030 Closed
VEA
142
Virtus ETF Advisers
New York
– -$69.2K -2,972 Closed
RS
143
R Squared
Hong Kong
– -$16.5K -710 Closed
VWM
144
Venturi Wealth Management
Texas
– -$5.38K -231 Closed
SMAM
145
Sugar Maple Asset Management
Wisconsin
– -$4.19K -180 Closed
BIG
146
Brooklyn Investment Group
New York
– -$2.79K -120 Closed
S
147
SignatureFD
Georgia
– -$1.58K -68 Closed
Simplex Trading
148
Simplex Trading
Illinois
– -$1K -55 Closed
PCWA
149
Pacific Capital Wealth Advisors
California
– -$186 -8 Closed
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