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Ikarian Capital’s Spyre Therapeutics SYRE Stock Holding History

Ikarian Capital’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q1 		– Sell
-282,159
Closed -$6.57M – 215
2024
Q4 		$6.57M Sell
282,159
-20,088
-7% -$589K 0.89% 32
2024
Q3 		$8.89M Buy
+302,247
New +$8.42M 1.24% 22

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
FFM
Fairmount Funds Management West Conshohocken, Pennsylvania $1.38B AUM 407.79% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
VA
VR Adviser New York $2.68B AUM 422.73% 1-Year Est. Return
B
Braidwell Stamford, Connecticut $3B AUM 46.72% 1-Year Est. Return
Capital International Investors
Capital International Investors Los Angeles, California $427B AUM 29.17% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return

Ikarian Capital's SYRE Position: Q1 2025 in Review

Ikarian Capital sold out of Spyre Therapeutics (SYRE) in Q1 2025, closing a stake of 282,159 shares — an estimated $6.57M sold.

Ikarian Capital first reported a position in SYRE in Q3 2024 and held it in 2 quarters. The position peaked at $8.89M in Q3 2024. 129 funds tracked by Wall St. Rank hold SYRE as of Q1 2025.

  • Ikarian Capital reported no remaining Spyre Therapeutics position as of Q1 2025 after selling out during the quarter.
  • Ikarian Capital sold 282,159 Spyre Therapeutics shares in Q1 2025, an estimated $6.57M.
  • Ikarian Capital first reported a position in Spyre Therapeutics in Q3 2024 and held it in 2 quarters.
  • Ikarian Capital's Spyre Therapeutics position peaked at $8.89M in Q3 2024.
  • 129 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q1 2025.

Based on Ikarian Capital's 13F filing for Q1 2025, filed 15 May 2025.