Simplex Trading
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Simplex Trading’s Spyre Therapeutics SYRE Stock Holding History

Simplex Trading’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q3 		– Sell
-145
Closed -$2.36K – 10047
2025
Q2 		$2K Buy
+145
New +$2.15K ﹤0.01% 8211
2025
Q1 		– Sell
-55
Closed -$1.14K – 9651
2024
Q4 		$1K Buy
+55
New +$1.61K ﹤0.01% 8323
2024
Q3 		– Sell
-64
Closed -$1K – 9554
2024
Q2 		$1K Buy
+64
New +$2.16K ﹤0.01% 8569
2023
Q3 		– Sell
-112
Closed -$1K – 9787
2023
Q2 		$1K Buy
112
+110
+5,500% +$522 ﹤0.01% 8726
2023
Q1 		$0 Hold
2
– – ﹤0.01% 10110
2022
Q4 		$0 Sell
2
-523
-100% -$9.4K ﹤0.01% 10401
2022
Q3 		$6K Buy
525
+524
+52,400% +$6.47K ﹤0.01% 8687
2022
Q2 		$0 Buy
+1
New +$35 ﹤0.01% 11068
2021
Q1 		– Sell
-5
Closed -$959 – 9993
2020
Q4 		$0 Buy
5
+2
+67% +$415 ﹤0.01% 9069
2020
Q3 		$0 Sell
3
-27
-90% -$5K ﹤0.01% 8495
2020
Q2 		$6K Buy
30
+29
+2,900% +$5.52K ﹤0.01% 6908
2020
Q1 		$0 Sell
1
-28
-97% -$4.76K ﹤0.01% 8248
2019
Q4 		$5K Sell
29
-23
-44% -$4.51K ﹤0.01% 6718
2019
Q3 		$10K Sell
52
-33
-39% -$6.43K ﹤0.01% 6262
2019
Q2 		$14K Buy
+85
New +$14.7K ﹤0.01% 5907

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
FFM
Fairmount Funds Management West Conshohocken, Pennsylvania $1.38B AUM 407.79% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
VA
VR Adviser New York $2.68B AUM 422.73% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return

Simplex Trading's SYRE Position: Q3 2025 in Review

Simplex Trading sold out of Spyre Therapeutics (SYRE) in Q3 2025, closing a stake of 145 shares — an estimated $2.36K sold.

Simplex Trading first reported a position in SYRE in Q2 2019 and held it in 15 quarters. The position peaked at $14K in Q2 2019. 137 funds tracked by Wall St. Rank hold SYRE as of Q3 2025.

  • Simplex Trading reported no remaining Spyre Therapeutics position as of Q3 2025 after selling out during the quarter.
  • Simplex Trading sold 145 Spyre Therapeutics shares in Q3 2025, an estimated $2.36K.
  • Simplex Trading first reported a position in Spyre Therapeutics in Q2 2019 and held it in 15 quarters.
  • Simplex Trading's Spyre Therapeutics position peaked at $14K in Q2 2019.
  • 137 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q3 2025.

Based on Simplex Trading's 13F filing for Q3 2025, filed 12 Nov 2025.