Simplex Trading
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Simplex Trading’s Spyre Therapeutics SYRE Stock Holding History

Simplex Trading’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$24.7K Buy
+278
New +$20.3K ﹤0.01% 6917
2025
Q3 		– Sell
-145
Closed -$2.36K – 10047
2025
Q2 		$2K Buy
+145
New +$2.15K ﹤0.01% 8211
2025
Q1 		– Sell
-55
Closed -$1.14K – 9651
2024
Q4 		$1K Buy
+55
New +$1.61K ﹤0.01% 8323
2024
Q3 		– Sell
-64
Closed -$1K – 9554
2024
Q2 		$1K Buy
+64
New +$2.16K ﹤0.01% 8569
2023
Q3 		– Sell
-112
Closed -$1K – 9787
2023
Q2 		$1K Buy
112
+110
+5,500% +$522 ﹤0.01% 8726
2023
Q1 		$0 Hold
2
– – ﹤0.01% 10110
2022
Q4 		$0 Sell
2
-523
-100% -$9.4K ﹤0.01% 10401
2022
Q3 		$6K Buy
525
+524
+52,400% +$6.47K ﹤0.01% 8687
2022
Q2 		$0 Buy
+1
New +$35 ﹤0.01% 11068
2021
Q1 		– Sell
-5
Closed -$959 – 9993
2020
Q4 		$0 Buy
5
+2
+67% +$415 ﹤0.01% 9069
2020
Q3 		$0 Sell
3
-27
-90% -$5K ﹤0.01% 8495
2020
Q2 		$6K Buy
30
+29
+2,900% +$5.52K ﹤0.01% 6908
2020
Q1 		$0 Sell
1
-28
-97% -$4.76K ﹤0.01% 8248
2019
Q4 		$5K Sell
29
-23
-44% -$4.51K ﹤0.01% 6718
2019
Q3 		$10K Sell
52
-33
-39% -$6.43K ﹤0.01% 6262
2019
Q2 		$14K Buy
+85
New +$14.7K ﹤0.01% 5907

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
RI
RTW Investments New York $11.7B AUM 174.13% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $5.34B AUM 380.18% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
VA
VR Adviser New York $3.3B AUM 525.74% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $17.3B AUM 211.34% 1-Year Est. Return

Simplex Trading's SYRE Position: Q2 2026 in Review

Simplex Trading opened a new position in Spyre Therapeutics (SYRE) in Q2 2026: 278 shares worth $24.7K. The stake represents ﹤0.01% of the portfolio and ranks #6917 among its holdings. This is a return to the name: Simplex Trading previously reported a position in SYRE as recently as Q2 2025.

Simplex Trading first reported a position in SYRE in Q2 2019 and has held it in 16 quarters since. 267 funds tracked by Wall St. Rank hold SYRE as of Q2 2026.

  • Simplex Trading held 278 shares of Spyre Therapeutics worth $24.7K as of Q2 2026.
  • Spyre Therapeutics was a new Simplex Trading position in Q2 2026.
  • Spyre Therapeutics made up ﹤0.01% of Simplex Trading's portfolio in Q2 2026, its #6917 holding.
  • Simplex Trading first reported a position in Spyre Therapeutics in Q2 2019 and has held it in 16 quarters since.
  • 267 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q2 2026.

Based on Simplex Trading's 13F filing for Q2 2026, filed 12 Aug 2026.