Simplex Trading
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Simplex Trading’s Spyre Therapeutics SYRE Stock Holding History

Simplex Trading’s Portfolio SYRE Stock Details SYRE Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-35,300
Closed -$1.16M – 10125
2025
Q4 		$1.16M Buy
+35,300
New +$922K ﹤0.01% 2490
2025
Q3 		– Sell
-300
Closed -$4K – 10048
2025
Q2 		$4K Buy
+300
New +$4.44K ﹤0.01% 7896
2023
Q3 		– Sell
-144
Closed -$1K – 9788
2023
Q2 		$1K Buy
+144
New +$683 ﹤0.01% 8727

Other funds holding SYRE

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
FFM
Fairmount Funds Management West Conshohocken, Pennsylvania $1.38B AUM 407.79% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
VA
VR Adviser New York $2.68B AUM 422.73% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return

Simplex Trading's SYRE Position: Q3 2025 in Review

Simplex Trading sold out of Spyre Therapeutics (SYRE) in Q3 2025, closing a stake of 145 shares — an estimated $2.36K sold.

Simplex Trading first reported a position in SYRE in Q2 2019 and held it in 15 quarters. The position peaked at $14K in Q2 2019. 137 funds tracked by Wall St. Rank hold SYRE as of Q3 2025.

  • Simplex Trading reported no remaining Spyre Therapeutics position as of Q3 2025 after selling out during the quarter.
  • Simplex Trading sold 145 Spyre Therapeutics shares in Q3 2025, an estimated $2.36K.
  • Simplex Trading first reported a position in Spyre Therapeutics in Q2 2019 and held it in 15 quarters.
  • Simplex Trading's Spyre Therapeutics position peaked at $14K in Q2 2019.
  • 137 funds tracked by Wall St. Rank held Spyre Therapeutics as of Q3 2025.

Based on Simplex Trading's 13F filing for Q3 2025, filed 12 Nov 2025.