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Spyre Therapeutics
SYRE

Overview Fund Activity

129 hedge funds and large institutions have $1B invested in Spyre Therapeutics in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 52 increasing their positions, 35 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
129
Holders Change
-2
Holders Change %
-1.53%
% of All Funds
1.75%
Holding in Top 10
2
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-50%
% of All Funds
0.03%
New
20
Increased
52
Reduced
35
Closed
21
Calls
$827K
Puts
$1.01M
Net Calls
-$182K
Net Calls Change
-$264K

Top Buyers

1
Capital International Investors
Capital International Investors
California
+$38.6M
2
TCM
Tang Capital Management
California
+$33.1M
3
PBA
Paradigm Biocapital Advisors
New York
+$9.68M
4
Bank of America
Bank of America
North Carolina
+$6.78M
5
Fidelity Investments
Fidelity Investments
Massachusetts
+$3.83M

Top Sellers

1
Citadel Advisors
Citadel Advisors
Florida
-$15.3M
2
LGM
Logos Global Management
California
-$11.6M
3
BCM
Boxer Capital Management
California
-$10.9M
4
Goldman Sachs
Goldman Sachs
New York
-$8.88M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$7.45M
Name Holding Trade Value Shares
Change 		Shares
Change %
HS
51
HighVista Strategies
Massachusetts
$1.54M – – –
Citigroup
52
Citigroup
New York
$1.35M +$157K +9,712 +13%
EAM
53
EFG Asset Management
Oregon
$1.33M -$5.58K -346 -0.4%
PM
54
Prosight Management
Texas
$1.21M -$82K -5,079 -6%
Squarepoint
55
Squarepoint
New York
$1.16M +$916K +56,780 +373%
Rafferty Asset Management
56
Rafferty Asset Management
New York
$1.13M -$104K -6,417 -8%
BGI
57
B Group Inc
Texas
$1.13M +$323K +20,000 +40%
Swiss National Bank
58
Swiss National Bank
Switzerland
$1.11M – – –
Susquehanna International Group
59
Susquehanna International Group
Pennsylvania
$947K +$575K +35,607 +154%
RhumbLine Advisers
60
RhumbLine Advisers
Massachusetts
$904K -$26.4K -1,634 -3%
BNP Paribas Financial Markets
61
BNP Paribas Financial Markets
France
$901K +$598K +37,049 +197%
Manulife (Manufacturers Life Insurance)
62
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$870K +$18.4K +1,139 +2%
UBS AM
63
UBS AM
Illinois
$841K +$50.9K +3,157 +6%
FMI
64
F/M Investments
District of Columbia
$837K +$49K +3,038 +6%
JPMorgan Chase & Co
65
JPMorgan Chase & Co
New York
$671K +$102K +6,308 +18%
WC
66
Wexford Capital
Florida
$618K +$618K +38,292 New
Legal & General Group
67
Legal & General Group
United Kingdom
$611K +$5.71K +354 +0.9%
AllianceBernstein
68
AllianceBernstein
Tennessee
$585K – – –
State of Wisconsin Investment Board
69
State of Wisconsin Investment Board
Wisconsin
$563K +$55.1K +3,417 +11%
California State Teachers Retirement System (CalSTRS)
70
California State Teachers Retirement System (CalSTRS)
California
$526K – – –
Wells Fargo
71
Wells Fargo
California
$485K +$85.8K +5,317 +22%
XT
72
XTX Topco
Cayman Islands
$460K +$460K +28,499 New
Deutsche Bank
73
Deutsche Bank
Germany
$460K -$47.4K -2,935 -9%
Mirae Asset Global ETFs Holdings
74
Mirae Asset Global ETFs Holdings
Hong Kong
$442K +$69.9K +4,277 +19%
TRSOTSOK
75
Teachers Retirement System of the State of Kentucky
Kentucky
$416K – – –
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3
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