SYRE icon

Spyre Therapeutics
SYRE

Overview Fund Activity

131 hedge funds and large institutions have $1.39B invested in Spyre Therapeutics in 2024 Q4 according to their latest regulatory filings, with 34 funds opening new positions, 63 increasing their positions, 20 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
131
Holders Change
+12
Holders Change %
+10.08%
% of All Funds
1.74%
Holding in Top 10
4
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+33.33%
% of All Funds
0.05%
New
34
Increased
63
Reduced
20
Closed
21
Calls
$161K
Puts
$79K
Net Calls
+$82K
Net Calls Change
+$102K

Top Buyers

1
DCM
1
Driehaus Capital Management
Illinois
$65.3M
2
Fidelity Investments
2
Fidelity Investments
Massachusetts
$205M
3
JFG
3
Jefferies Financial Group
New York
$28.3M
4
BlackRock
4
BlackRock
New York
$79.1M
5
Goldman Sachs
5
Goldman Sachs
New York
$17.4M

Top Sellers

1
Assenagon Asset Management
1
Assenagon Asset Management
Luxembourg
$527K
2
DTC
2
Deep Track Capital
Connecticut
$5.1M
3
ACA
3
Avoro Capital Advisors
New York
$0
4
Walleye Capital
4
Walleye Capital
New York
$0
5
PA
5
Perceptive Advisors
New York
$59.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
Mirae Asset Global ETFs Holdings
76
Mirae Asset Global ETFs Holdings
Hong Kong
$527K +$21.2K +916 +4%
MIM
77
MetLife Investment Management
New Jersey
$498K +$29.1K +1,250 +6%
Invesco
78
Invesco
Georgia
$458K -$2.75M -118,195 -86%
CCM
79
Cinctive Capital Management
New York
$456K -$971K -41,689 -68%
NC
80
NBW Capital
Massachusetts
$452K -$175K -7,500 -28%
BNP Paribas Financial Markets
81
BNP Paribas Financial Markets
France
$437K +$437K +18,784 New
GEM
82
Global Endowment Management
North Carolina
$423K – – –
Natixis Advisors
83
Natixis Advisors
Massachusetts
$403K +$403K +17,300 New
CF
84
Corebridge Financial
Texas
$401K -$30.2K -1,299 -7%
BHCM
85
Brevan Howard Capital Management
Jersey
$393K +$393K +16,899 New
ECM
86
ExodusPoint Capital Management
New York
$389K +$162K +6,958 +71%
Squarepoint
87
Squarepoint
New York
$355K +$157K +6,754 +80%
PA
88
Profund Advisors
Maryland
$346K +$18.3K +787 +6%
IIM
89
INTECH Investment Management
Florida
$327K +$132K +5,672 +68%
ProShare Advisors
90
ProShare Advisors
Maryland
$292K +$292K +12,531 New
CUAMC
91
China Universal Asset Management Company
China
$290K +$290K +12,440 New
ACM
92
Aquatic Capital Management
Illinois
$274K +$274K +11,767 New
VOYA Investment Management
93
VOYA Investment Management
Georgia
$244K -$19.9K -856 -8%
Teacher Retirement System of Texas
94
Teacher Retirement System of Texas
Texas
$242K +$242K +10,383 New
New York State Common Retirement Fund
95
New York State Common Retirement Fund
New York
$239K – – –
ASRS
96
Arizona State Retirement System
Arizona
$235K +$65.3K +2,805 +38%
Two Sigma Investments
97
Two Sigma Investments
New York
$224K -$3.84K -165 -2%
CG
98
Carlyle Group
District of Columbia
$224K – – –
State Board of Administration of Florida Retirement System
99
State Board of Administration of Florida Retirement System
Florida
$210K – – –
TRCT
100
Tower Research Capital (TRC)
New York
$200K +$187K +8,054 +1,549%
2 3
4
5 6