Spyre Therapeutics
SYRE
SYRE
129 hedge funds and large institutions have $953M invested in Spyre Therapeutics in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 64 increasing their positions, 25 reducing their positions, and 17 closing their positions.
New
Increased
Maintained
Reduced
Closed
more repeat investments, than reductions
Existing positions increased: | Existing positions reduced:
more call options, than puts
Call options by funds: $ | Put options by funds: $
more funds holding in top 10
Funds holding in top 10: →
more ownership
Funds ownership: →
6% more first-time investments, than exits
New positions opened: 18 | Existing positions closed: 17
0% more funds holding
Funds holding: 129 → 129 (0)
5% less capital invested
Capital invested by funds: $1B → $953M (-$51.7M)
Holders
129
Holding in Top 10
3
Calls
$1.05M
Puts
$603K
Top Buyers
| 1 | +$17M | |
| 2 | +$10.1M | |
| 3 | +$9.27M | |
| 4 |
BlackRock
New York
|
+$6.43M |
| 5 |
Morgan Stanley
New York
|
+$4.97M |
Top Sellers
| 1 | -$15.2M | |
| 2 | -$11.6M | |
| 3 | -$9.35M | |
| 4 |
PBA
Paradigm Biocapital Advisors
New York
|
-$3.8M |
| 5 |
Adage Capital Partners
Boston,
Massachusetts
|
-$2.86M |