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Spyre Therapeutics
SYRE

Overview Fund Activity

131 hedge funds and large institutions have $1.39B invested in Spyre Therapeutics in 2024 Q4 according to their latest regulatory filings, with 34 funds opening new positions, 63 increasing their positions, 20 reducing their positions, and 21 closing their positions.

Holders
131
Holders Change
+12
Holders Change %
+10.08%
% of All Funds
1.74%
Holding in Top 10
4
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+33.33%
% of All Funds
0.05%
New
34
Increased
63
Reduced
20
Closed
21
Calls
$161K
Puts
$79K
Net Calls
+$82K
Net Calls Change
+$102K

Top Buyers

1
DCM
1
Driehaus Capital Management
Illinois
$65.3M
2
Fidelity Investments
2
Fidelity Investments
Massachusetts
$205M
3
JFG
3
Jefferies Financial Group
New York
$28.3M
4
BlackRock
4
BlackRock
New York
$79.1M
5
Goldman Sachs
5
Goldman Sachs
New York
$17.4M

Top Sellers

1
Assenagon Asset Management
1
Assenagon Asset Management
Luxembourg
$527K
2
DTC
2
Deep Track Capital
Connecticut
$5.1M
3
ACA
3
Avoro Capital Advisors
New York
$0
4
Walleye Capital
4
Walleye Capital
New York
$0
5
PA
5
Perceptive Advisors
New York
$59.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
HS
51
HighVista Strategies
Massachusetts
$2.22M -$237K -10,192 -10%
BFM
52
Boothbay Fund Management
New York
$1.99M -$143K -6,157 -7%
EAM
53
EFG Asset Management
Oregon
$1.93M +$713K +30,608 +59%
Ensign Peak Advisors
54
Ensign Peak Advisors
Utah
$1.92M – – –
PM
55
Prosight Management
Texas
$1.86M +$1.86M +80,000 New
Rafferty Asset Management
56
Rafferty Asset Management
New York
$1.79M +$143K +6,154 +9%
Citigroup
57
Citigroup
New York
$1.72M +$1.13M +48,561 +193%
Swiss National Bank
58
Swiss National Bank
Switzerland
$1.6M +$442K +19,000 +38%
TD Asset Management
59
TD Asset Management
Ontario, Canada
$1.51M +$284K +12,200 +23%
RhumbLine Advisers
60
RhumbLine Advisers
Massachusetts
$1.34M +$86.6K +3,722 +7%
Manulife (Manufacturers Life Insurance)
61
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$1.23M +$217K +9,302 +21%
BGI
62
B Group Inc
Texas
$1.16M +$1.16M +50,000 New
UBS AM
63
UBS AM
Illinois
$1.14M +$525K +22,540 +85%
FMI
64
F/M Investments
District of Columbia
$1.14M +$1.14M +48,806 New
Legal & General Group
65
Legal & General Group
United Kingdom
$873K +$194K +8,335 +29%
AllianceBernstein
66
AllianceBernstein
Tennessee
$843K – – –
JPMorgan Chase & Co
67
JPMorgan Chase & Co
New York
$821K +$134K +5,775 +20%
California State Teachers Retirement System (CalSTRS)
68
California State Teachers Retirement System (CalSTRS)
California
$759K +$184K +7,923 +32%
State of Wisconsin Investment Board
69
State of Wisconsin Investment Board
Wisconsin
$733K +$307K +13,169 +72%
Deutsche Bank
70
Deutsche Bank
Germany
$731K +$231K +9,910 +46%
TRSOTSOK
71
Teachers Retirement System of the State of Kentucky
Kentucky
$601K +$108K +4,645 +22%
Wells Fargo
72
Wells Fargo
California
$575K +$161K +6,908 +39%
First Trust Advisors
73
First Trust Advisors
Illinois
$548K +$548K +23,550 New
Susquehanna International Group
74
Susquehanna International Group
Pennsylvania
$538K +$230K +9,891 +75%
Assenagon Asset Management
75
Assenagon Asset Management
Luxembourg
$527K -$26.1M -1,120,116 -98%
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