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Spyre Therapeutics
SYRE

Overview Fund Activity

54 hedge funds and large institutions have $601M invested in Spyre Therapeutics in 2023 Q4 according to their latest regulatory filings, with 29 funds opening new positions, 16 increasing their positions, 5 reducing their positions, and 4 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
54
Holders Change
+25
Holders Change %
+86.21%
% of All Funds
0.79%
Holding in Top 10
3
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+200%
% of All Funds
0.04%
New
29
Increased
16
Reduced
5
Closed
4
Calls
$44K
Puts
–
Net Calls
+$44K
Net Calls Change
+$11K

Top Buyers

1
Fidelity Investments
1
Fidelity Investments
Massachusetts
$79.7M
2
PA
2
Perceptive Advisors
New York
$56.1M
3
RI
3
RTW Investments
New York
$48M
4
VA
4
VR Adviser
New York
$51.1M
5
DTC
5
Deep Track Capital
Connecticut
$42M

Top Sellers

1
RSCM
1
Rock Springs Capital Management
Maryland
$0
2
LGM
2
Logos Global Management
California
$3.23M
3
ACM
3
Aisling Capital Management
New York
$0
4
DCM
4
Driehaus Capital Management
Illinois
$16.6M
5
YF
5
Yu Fan
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
LGM
26
Logos Global Management
California
$3.23M -$1.29M -60,000 -29%
GPP
27
Great Point Partners
Connecticut
$2.69M +$2.69M +125,000 New
Millennium Management
28
Millennium Management
New York
$2.33M +$1.52M +70,673 +187%
PM
29
Prosight Management
Texas
$1.18M +$1.18M +55,000 New
Renaissance Technologies
30
Renaissance Technologies
New York
$1.04M +$544K +25,307 +109%
Barclays
31
Barclays
United Kingdom
$979K +$979K +45,498 New
Vanguard Group
32
Vanguard Group
Pennsylvania
$849K +$137K +6,369 +19%
Geode Capital Management
33
Geode Capital Management
Massachusetts
$653K +$75.9K +3,526 +13%
Two Sigma Investments
34
Two Sigma Investments
New York
$605K +$605K +28,095 New
ECM
35
ExodusPoint Capital Management
New York
$564K +$564K +26,210 New
CSS
36
Cubist Systematic Strategies
Connecticut
$563K +$563K +26,150 New
Marshall Wace
37
Marshall Wace
United Kingdom
$436K +$436K +20,252 New
Blackstone Inc
38
Blackstone Inc
New York
$430K +$430K +19,991 New
BlackRock
39
BlackRock
New York
$425K -$129 -6 -0%
Citigroup
40
Citigroup
New York
$222K +$222K +10,297 New
CG
41
Carlyle Group
District of Columbia
$204K +$204K +9,620 New
ACM
42
ADAR1 Capital Management
Texas
$139K +$139K +6,440 New
VEA
43
Virtus ETF Advisers
New York
$134K +$134K +6,239 New
UBS Group
44
UBS Group
Switzerland
$80.2K +$80.2K +3,726 New
TRCT
45
Tower Research Capital (TRC)
New York
$55.5K +$46.4K +2,158 +511%
Acadian Asset Management
46
Acadian Asset Management
Massachusetts
$25K -$229K -10,719 -90%
New York State Common Retirement Fund
47
New York State Common Retirement Fund
New York
$8K +$8K +365 New
Osaic Holdings
48
Osaic Holdings
Arizona
$6.09K – – –
IA
49
IFP Advisors
Florida
$2.45K -$61.5K -2,860 -96%
Morgan Stanley
50
Morgan Stanley
New York
$1.72K +$732 +34 +74%
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