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Spyre Therapeutics
SYRE

Overview Fund Activity

29 hedge funds and large institutions have $43.9M invested in Spyre Therapeutics in 2023 Q3 according to their latest regulatory filings, with 3 funds opening new positions, 11 increasing their positions, 12 reducing their positions, and 17 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
29
Holders Change
-14
Holders Change %
-32.56%
% of All Funds
0.46%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.02%
New
3
Increased
11
Reduced
12
Closed
17
Calls
$33K
Puts
–
Net Calls
+$33K
Net Calls Change
+$34K

Top Buyers

1
DCM
1
Driehaus Capital Management
Illinois
$9.81M
2
PCH
2
Polar Capital Holdings
United Kingdom
$3.68M
3
Citadel Advisors
3
Citadel Advisors
Florida
$1.19M
4
LGM
4
Logos Global Management
California
$2.57M
5
PA
5
Perceptive Advisors
New York
$994K

Top Sellers

1
NCM
1
Nantahala Capital Management
Connecticut
$0
2
BBA
2
Baker Bros. Advisors
New York
$0
3
Millennium Management
3
Millennium Management
New York
$463K
4
Wellington Management Group
4
Wellington Management Group
Massachusetts
$3.67M
5
Acadian Asset Management
5
Acadian Asset Management
Massachusetts
$145K
Name Holding Trade Value Shares
Change 		Shares
Change %
IA
26
IFP Advisors
Florida
$3.12K +$3K +2,860 +2,509%
Morgan Stanley
27
Morgan Stanley
New York
$564 -$1.05K -86 -65%
JPMorgan Chase & Co
28
JPMorgan Chase & Co
New York
$502 -$24 -2 -5%
Wells Fargo
29
Wells Fargo
California
$270 -$4.03K -328 -94%
NCM
30
Nantahala Capital Management
Connecticut
– -$1.85M -164,048 Closed
BBA
31
Baker Bros. Advisors
New York
– -$1.54M -136,404 Closed
SB
32
Samsara BioCapital
California
– -$398K -35,349 Closed
Goldman Sachs
33
Goldman Sachs
New York
– -$252K -22,346 Closed
UOTTAIMCU
34
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
– -$111K -9,827 Closed
CG
35
Carlyle Group
District of Columbia
– -$108K -9,620 Closed
State Street
36
State Street
Massachusetts
– -$87.9K -7,804 Closed
HF
37
HRT Financial
New York
– -$74K -6,581 Closed
Northern Trust
38
Northern Trust
Illinois
– -$44.1K -3,917 Closed
Jane Street
39
Jane Street
New York
– -$24.5K -2,171 Closed
Susquehanna International Group
40
Susquehanna International Group
Pennsylvania
– -$16.3K -1,447 Closed
Franklin Resources
41
Franklin Resources
California
– -$14.1K -1,255 Closed
Bank of New York Mellon
42
Bank of New York Mellon
New York
– -$10.5K -929 Closed
UBS Group
43
UBS Group
Switzerland
– -$3.65K -324 Closed
Simplex Trading
44
Simplex Trading
Illinois
– -$1K -112 Closed
Group One Trading
45
Group One Trading
Illinois
– -$258 -23 Closed
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