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Spyre Therapeutics
SYRE

Overview Fund Activity

131 hedge funds and large institutions have $1.39B invested in Spyre Therapeutics in 2024 Q4 according to their latest regulatory filings, with 34 funds opening new positions, 63 increasing their positions, 20 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
131
Holders Change
+12
Holders Change %
+10.08%
% of All Funds
1.74%
Holding in Top 10
4
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+33.33%
% of All Funds
0.05%
New
34
Increased
63
Reduced
20
Closed
21
Calls
$161K
Puts
$79K
Net Calls
+$82K
Net Calls Change
+$102K

Top Buyers

1
DCM
1
Driehaus Capital Management
Illinois
$65.3M
2
Fidelity Investments
2
Fidelity Investments
Massachusetts
$205M
3
JFG
3
Jefferies Financial Group
New York
$28.3M
4
BlackRock
4
BlackRock
New York
$79.1M
5
Goldman Sachs
5
Goldman Sachs
New York
$17.4M

Top Sellers

1
Assenagon Asset Management
1
Assenagon Asset Management
Luxembourg
$527K
2
DTC
2
Deep Track Capital
Connecticut
$5.1M
3
ACA
3
Avoro Capital Advisors
New York
$0
4
Walleye Capital
4
Walleye Capital
New York
$0
5
PA
5
Perceptive Advisors
New York
$59.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
LGM
26
Logos Global Management
California
$11.6M +$6.98M +300,000 +150%
BCM
27
Boxer Capital Management
California
$10.9M +$10.9M +466,680 New
DM
28
Deerfield Management
New York
$10.5M +$10.5M +450,000 New
Blackstone Inc
29
Blackstone Inc
New York
$10.5M +$3.64M +156,206 +53%
UBS Group
30
UBS Group
Switzerland
$9.13M +$7.78M +334,359 +578%
EMFAT
31
Emerald Mutual Fund Advisers Trust
Pennsylvania
$9M +$3.09M +132,834 +52%
Charles Schwab
32
Charles Schwab
California
$8.84M +$1.08M +46,375 +14%
Capital World Investors
33
Capital World Investors
California
$8.81M +$8.81M +378,573 New
SL
34
Siren LLC
Connecticut
$8.71M +$8.71M +374,000 New
WP
35
Woodline Partners
California
$8.21M +$2.06M +88,424 +33%
Northern Trust
36
Northern Trust
Illinois
$8.12M +$808K +34,693 +11%
IC
37
Ikarian Capital
Texas
$6.57M -$468K -20,088 -7%
Victory Capital Management
38
Victory Capital Management
Texas
$6.24M +$6.24M +268,076 New
Morgan Stanley
39
Morgan Stanley
New York
$5.94M +$268K +11,514 +5%
SFM
40
Soros Fund Management
New York
$5.82M +$2.44M +105,000 +72%
CS
41
Candriam SCA
Luxembourg
$5.76M +$3.32M +142,591 +136%
DTC
42
Deep Track Capital
Connecticut
$5.1M -$18.2M -780,985 -78%
AC
43
Armistice Capital
New York
$4.66M +$1.49M +64,000 +47%
Millennium Management
44
Millennium Management
New York
$3.91M +$3.91M +167,804 New
Nuveen Asset Management
45
Nuveen Asset Management
Illinois
$2.93M +$8.8K +378 +0.3%
Barclays
46
Barclays
United Kingdom
$2.87M +$410K +17,604 +17%
Universal-Beteiligungs- und Servicegesellschaft
47
Universal-Beteiligungs- und Servicegesellschaft
Germany
$2.84M +$2.84M +122,153 New
Voloridge Investment Management
48
Voloridge Investment Management
Florida
$2.69M -$955K -41,011 -26%
Schroder Investment Management Group
49
Schroder Investment Management Group
United Kingdom
$2.56M +$2.56M +113,620 New
Bank of New York Mellon
50
Bank of New York Mellon
New York
$2.41M -$26K -1,118 -1%
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