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Spyre Therapeutics
SYRE

Overview Fund Activity

43 hedge funds and large institutions have $31.9M invested in Spyre Therapeutics in 2023 Q2 according to their latest regulatory filings, with 15 funds opening new positions, 4 increasing their positions, 8 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
43
Holders Change
-1
Holders Change %
-2.27%
% of All Funds
0.68%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.03%
New
15
Increased
4
Reduced
8
Closed
16
Calls
–
Puts
$1K
Net Calls
-$1K
Net Calls Change
-$1K

Top Buyers

1
FFM
1
Fairmount Funds Management
Pennsylvania
$4.26M
2
Wellington Management Group
2
Wellington Management Group
Massachusetts
$3.97M
3
VA
3
VR Adviser
New York
$2.86M
4
EC
4
EcoR1 Capital
California
$2.25M
5
AAA
5
Affinity Asset Advisors
New York
$2.21M

Top Sellers

1
BCLSI
1
Bain Capital Life Sciences Investors
Massachusetts
$0
2
SCM
2
Sio Capital Management
New York
$0
3
Vanguard Group
3
Vanguard Group
Pennsylvania
$292K
4
Millennium Management
4
Millennium Management
New York
$1.11M
5
O
5
OrbiMed
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
HF
26
HRT Financial
New York
$74K +$74K +6,581 New
YF
27
Yu Fan
$50.5K – – –
Northern Trust
28
Northern Trust
Illinois
$44.1K – – –
Jane Street
29
Jane Street
New York
$24.5K +$5.18K +460 +27%
Susquehanna International Group
30
Susquehanna International Group
Pennsylvania
$16.3K +$16.3K +1,447 New
Franklin Resources
31
Franklin Resources
California
$14.1K – – –
Bank of New York Mellon
32
Bank of New York Mellon
New York
$10.5K – – –
TRCT
33
Tower Research Capital (TRC)
New York
$10.3K -$6.6K -585 -39%
Wells Fargo
34
Wells Fargo
California
$3.94K +$236 +21 +6%
UBS Group
35
UBS Group
Switzerland
$3.65K +$3.65K +324 New
Osaic Holdings
36
Osaic Holdings
Arizona
$2.25K +$2.25K +200 New
Morgan Stanley
37
Morgan Stanley
New York
$1.49K -$4.67K -414 -76%
IA
38
IFP Advisors
Florida
$1.29K – – –
Royal Bank of Canada
39
Royal Bank of Canada
Ontario, Canada
$1K +$1K +53 New
Simplex Trading
40
Simplex Trading
Illinois
$1K +$982 +110 +5,500%
JPMorgan Chase & Co
41
JPMorgan Chase & Co
New York
$481 – – –
Group One Trading
42
Group One Trading
Illinois
$258 -$1.03K -92 -80%
BCLSI
43
Bain Capital Life Sciences Investors
Massachusetts
– -$1.55M -213,908 Closed
SCM
44
Sio Capital Management
New York
– -$871K -120,198 Closed
O
45
OrbiMed
New York
– -$521K -71,889 Closed
Adage Capital Partners
46
Adage Capital Partners
Massachusetts
– -$435K -60,000 Closed
SFM
47
Sphera Funds Management
Israel
– -$187K -25,859 Closed
Two Sigma Investments
48
Two Sigma Investments
New York
– -$92.9K -12,820 Closed
Assenagon Asset Management
49
Assenagon Asset Management
Luxembourg
– -$92.4K -12,738 Closed
Two Sigma Advisers
50
Two Sigma Advisers
New York
– -$61.1K -8,432 Closed
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